Involvement of Hydra achaete-scute gene CnASH in the differentiation pathway of sensory neurons in the tentacles

Development Genes and Evolution
Eisuke HayakawaToshitaka Fujisawa

Abstract

The proneural genes of achaete-scute (ac-sc) family that encodes the bHLH class transcription factors play a variety of roles in neurogenesis. In Hydra, the ac-sc homologue CnASH is involved in nematocyte differentiation. In the present study, we found that sensory neurons in the tentacles expressed CnASH, in addition to differentiating nematocytes in the body column of Hydra. Neuron precursors that migrated to the tentacle base did not express CnASH, and it took 1 day for them to become CnASH-expressing neurons. Thus, the CnASH-positive cells at the tentacle base appeared to be sensory cells at early stages of differentiation. Furthermore, the CnASH-positive neurons distributed from the base to the tip of tentacles suggest that the gene is also involved in maintenance of the differentiated state. In addition, we found that the sensory neurons in the tentacles consist of at least two subpopulations. The comparison of the CnASH expression with Nv1 expression in sensory cells that is detected by monoclonal antibody Nv1 showed that at least Nv1-positive/ CnASH-positive and Nv1-negative/ CnASH-positive sensory neurons existed in the tentacles.

Citations

Oct 14, 2008·Development Genes and Evolution·Nagayasu NakanishiVolker Hartenstein
Feb 3, 2009·Development Genes and Evolution·Toshio TakahashiToshitaka Fujisawa
Aug 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·José Luis RoyoJosé Luis Gómez-Skarmeta
Apr 22, 2009·Development, Growth & Differentiation·Hiroshi WatanabeThomas W Holstein
Mar 7, 2012·BMC Biology·Thomas W Holstein
Sep 19, 2009·Seminars in Cell & Developmental Biology·Hiroshi WatanabeThomas W Holstein
Sep 27, 2007·The FEBS Journal·Eisuke HayakawaToshitaka Fujisawa
Sep 21, 2011·The European Journal of Neuroscience·Brigitte Galliot, Manon Quiquand
Apr 29, 2006·Brain Research·Bernd FritzschKirk W Beisel
Jun 30, 2006·Seminars in Cell & Developmental Biology·Brigitte GalliotSimona Chera
Feb 25, 2015·Developmental Cell·Volker Hartenstein, Angelika Stollewerk
Mar 1, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S Guertin, G Kass-Simon
Mar 19, 2011·Cell·Isabelle S Peter, Eric H Davidson
Jun 7, 2005·Developmental Biology·Katja Seipel, Volker Schmid
May 26, 2009·Developmental Biology·Brigitte GalliotSimona Chera
May 10, 2018·Integrative and Comparative Biology·Gerhard Schlosser
Nov 11, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Detlev ArendtHeather Marlow
Feb 16, 2007·Development·Marijana Miljkovic-LicinaBrigitte Galliot

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