Involvement of IL-1β and IL-6 in antiarrhythmic properties of atorvastatin in ouabain-induced arrhythmia in rats

Immunopharmacology and Immunotoxicology
Mahya NajjariVahid Nikoui

Abstract

Evidence show that statins possess wide beneficial cardioprotective and anti-inflammatory effects; therefore, in the present experiment, we investigated the antiarrhythmic properties of atorvastatin in ouabain-induced arrhythmia in isolated rat atria and the role of several inflammatory cytokines in this effect. Male rats were pretreated with either of atorvastatin (10 mg/kg) or vehicle, orally once daily for 6 weeks. After induction of anesthesia, we isolated the atria and after incubation with ouabain, time of onset of arrhythmia and asystole as well as atrial beating rate and contractile force were recorded. We also measured the atrial levels of IL-1β, IL-6, and TNF-α after the injection of ouabain to animals. Pretreatment with atorvastatin significantly delayed the onset of arrhythmia and asystole compared with vehicle-treated group (p < .01, p < .001, respectively). Incubation of ouabain boosted both atrial beating rate and contractile force in vehicle-treated group (p < .05), while these responses in atorvastatin-treated group were not significant (p > .05). Injection of ouabain elevated the atrial levels of IL-1β, IL-6, and TNF-α, while pretreatment of animals with atorvastatin could reverse the ouabain-induced increase ...Continue Reading

References

May 29, 1998·Circulation·P W WilsonW B Kannel
Oct 28, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S Wan, A P Yim
Mar 8, 2000·Cytokine·A MatsumoriS Sasayama
Oct 7, 2000·Stroke; a Journal of Cerebral Circulation·N VilaA Chamorro
Aug 11, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·L DiomedeM Salmona
Jan 5, 2002·Current Atherosclerosis Reports·Christopher C Case, Christie M Ballantyne
Feb 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Sven WassmannGeorg Nickenig
Oct 9, 2002·Trends in Pharmacological Sciences·Gabriele Weitz-Schmidt
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Barry LondonGuy Salama
Nov 9, 2002·The American Journal of Cardiology·Claude GagnéUNKNOWN Ezetimibe Study Group
Dec 11, 2002·Kidney International·Luis Miguel Blanco-ColioJesús Egido
Mar 5, 2003·The American Journal of Cardiology·Peter Libby, Masanori Aikawa
Jun 25, 2005·European Heart Journal·Mads D M Engelmann, Jesper Hastrup Svendsen
Nov 5, 2005·Molecular Nutrition & Food Research·Daniel Steinberg
Dec 13, 2005·Nature Reviews. Drug Discovery·Mukesh K Jain, Paul M Ridker
Jan 28, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Keiichi IshidaMasaru Miyazaki
Feb 14, 2006·Stroke; a Journal of Cerebral Circulation·Sudhir KurlJukka T Salonen
Jun 3, 2006·Bioscience Reports·Sandra Rodrigues-MascarenhasVivian M Rumjanek
Nov 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Sam E SawayaDirar S Khoury
Jan 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Ken UmetaniKiyotaka Kugiyama
Aug 9, 2008·Clinical Interventions in Aging·Subroto Acharjee, Francine K Welty
Aug 30, 2008·QJM : Monthly Journal of the Association of Physicians·J Sánchez-QuiñonesG Y H Lip
Dec 22, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Gregory M MarcusJeffrey E Olgin
Nov 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Polina S Petkova-KirovaVladimir E Bondarenko
Mar 1, 2012·Current Pharmaceutical Design·Alexios S AntonopoulosCharalambos Antoniades
May 15, 2012·Stroke; a Journal of Cerebral Circulation·Karen L Furie
May 23, 2012·Circulation·Pasquale PignatelliFrancesco Violi
Mar 8, 2014·European Journal of Clinical Investigation·Gian Marco RosaFabrizio Montecucco
Jul 19, 2014·BMJ : British Medical Journal·Chintan S DesaiRoger S Blumenthal
Jan 15, 2016·Canadian Journal of Physiology and Pharmacology·Saeed MehrzadiHabib Ghaznavi
Nov 15, 2016·International Journal of Cardiology·Sikarin UpalaAnawin Sanguankeo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.