Involvement of IL-1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts

FEBS Letters
Natsuko UekawaMitsuo Maruyama

Abstract

Senescence of mammalian cultured cells is essentially organized by a machinery of cell division and cellular stresses induced by various extracellular stimuli. Here, we show that in mouse embryonic fibroblasts (MEFs) culture in vitro, expression of an inflammatory cytokine, interleukin-1beta (IL-1beta) and its antagonist, IL-1 receptor antagonist (IL-1Ra) are induced by senescence. The kinetics of IL-1beta-expression was similar to that of p38 activation during MEFs culture. We also found a distinguishable accelerated senescence in cell growth in IL-1Ra deficient MEFs culture. Our results suggest that IL-1beta signaling pathway is involved in activation of p38 linked cellular senescence.

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Citations

Mar 9, 2005·Biochemical and Biophysical Research Communications·Natsuko UekawaMitsuo Maruyama
Apr 8, 2006·Immunity & Ageing : I & a·Massimo MariottiJeanette A M Maier
Feb 20, 2008·FEBS Letters·Rachael M DewberrySheila E Francis
Apr 10, 2016·Biochemical and Biophysical Research Communications·Shun XuXinguang Liu
Mar 26, 2011·The American Journal of Pathology·Klaus KratochwillChristoph Aufricht
Apr 3, 2009·Biochemical and Biophysical Research Communications·Takeshi WakohMitsuo Maruyama
Jun 28, 2017·Free Radical Biology & Medicine·Justyna Mikuła-PietrasikKrzysztof Książek
Jul 13, 2019·Frontiers in Aging Neuroscience·Carolina OsorioAdonis Sfera
Jun 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuxin WangHuiming Ma
Dec 12, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Juliane L BuhlTill Milde
Jan 2, 2021·Ageing Research Reviews·Eva PrašnikarAndrej Perdih

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