Involvement of IL-4 in human glomerulonephritis: an in situ hybridization study of IL-4 mRNA and IL-4 receptor mRNA.

Journal of the American Society of Nephrology : JASN
A FurusuS Kohno

Abstract

Interleukin-4 (IL-4) has been recently implicated in the pathogenesis of glomerulonephritis. However, the expression of IL-4 and IL-4 receptor (IL-4R) in human kidney has not been fully determined. Nonradioactive in situ hybridization was used to examine the expression of IL-4 mRNA and IL-4R mRNA in tissues from normal kidneys and specimens from a variety of human kidney diseases. In normal glomeruli, a few mesangial cells and cells of the Bowman's capsule weakly expressed IL-4 and IL-4R mRNA, whereas in diseased glomeruli both mRNA types were strongly expressed in resident glomerular cells, including mesangial cells, glomerular epithelial cells, and cells of the Bowman's capsule. The relationship between the expression of these mRNA and the degree of glomerular injury was different in different types of glomerulonephritis. In IgA nephropathy and non-IgA mesangial proliferative glomerulonephritis, IL-4 expression correlated positively with the degree of mesangial hypercellularity and extracellular matrix expansion. However, IL-4R expression was relatively constant. In contrast, the expression of IL-4 and IL-4R mRNA correlated negatively with the degree of glomerular injury in lupus nephritis. Coexpression and discordant express...Continue Reading

Citations

Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F NogakiS Sasayama
Aug 13, 2013·The Journal of Biological Chemistry·Hag Dong KimJeongwon Sohn
Sep 1, 1999·International Journal of Experimental Pathology·B M RügerP F Davis
Oct 19, 1999·Biochimica Et Biophysica Acta·G ChenN Maruyama
Oct 11, 2001·Arthritis and Rheumatism·K MasutaniH Hirakata
May 7, 1999·Kidney International·M Kitamura, L G Fine
Jan 13, 2005·American Journal of Nephrology·Chie Miyake-OgawaShigeru Kohno
Mar 1, 2005·Lupus·M Aringer, J S Smolen
Sep 18, 2002·Kidney International·Michael EikmansJan A Bruijn
Sep 12, 2000·The American Journal of Pathology·J R PrattS H Sacks

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