Involvement of interferon-γ in bowel disease pathogenesis by nitric oxide pathway: a study in Algerian patients

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Hayet RafaChafia Touil-Boukoffa

Abstract

The pathogenesis of inflammatory bowel disease (IBD) is complex, involving a wide range of molecules including cytokines. Abnormalities in the expression of immunoregulatory cytokines such as interferon-γ (IFN-γ) and interleukin-12 (IL-12) may indicate a dysregulation of intestinal immunity probably associated with pathogenic events. The aim of this work was to study the implication of IFN-γ and nitric oxide (NO) in bowel disease pathogenesis. In this study, we investigated the circulating IFN-γ and IL-12 production in 2 groups of Algerian patients with IBD (Crohn's disease and ulcerative colitis). Moreover, systemic NO concentrations and NO generation by colonic mucosa were determined in these patients. Finally, we examined the effect of IFN-γ on NO production by peripheral blood mononuclear cells (PBMCs) of these patients. Our results indicate that IFN-γ/IL-12 production in IBD patients was increased in comparison to healthy donors. This strong production correlates with high levels of NO in sera and colonic mucosa culture. Interestingly, NO production was related to the clinical stage of IBD patients (inactive or active stage). The relationship between IFN-γ and NO production in IBD patients were confirmed by in vitro experi...Continue Reading

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Citations

Oct 23, 2013·Biosensors & Bioelectronics·Yu ChenSunil K Arya
Mar 12, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hayet RafaChafia Touil-Boukoffa
Sep 8, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Imene SoufliChafia Touil-Boukoffa
Oct 1, 2019·The Journal of Clinical Investigation·Victoria LangerMichael Stürzl
Mar 1, 2020·European Journal of Immunology·Julian J Freen-van HeerenMonika C Wolkers
Mar 18, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Tsuneya IkezuZbigniew K Wszolek
Feb 18, 2017·Immunopharmacology and Immunotoxicology·Amina Arroul-LammaliChafia Touil-Boukoffa
Mar 5, 2021·International Journal of Medical Microbiology : IJMM·Iris StolzerClaudia Günther
Jun 19, 2021·Frontiers in Medicine·Iris StolzerClaudia Günther

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Methods Mentioned

BETA
density gradient centrifugation
biopsies
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

DeclareMathSizes

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