Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer's disease

Journal of Neuroinflammation
Arnaud FrançoisGuylène Page

Abstract

Autophagy is a major pathway of protein and organelle degradation in the lysosome. Autophagy exists at basal constitutive level and can be induced as a defense mechanism under stress conditions. Molecular relationships between autophagy and inflammation at the periphery were recently evidenced, highlighting a role of autophagy in the regulation of inflammation. Impairment of autophagy (with accumulation of autophagic vacuoles) and substantial inflammation are found in neurodegenerative diseases such as Alzheimer's Disease (AD). However, the links between autophagy and inflammation in AD remain to be determined. Here, we examined the inflammatory reaction and autophagy in murine tri-cultures of neurons, astrocytes, and microglia. Tri-cultures were exposed to various inflammatory stresses (lipopolysaccharide (LPS), amyloid peptide (Aβ42) with or without cytokines) for 48 hours. Furthermore, the relationships between inflammation and autophagy were also analyzed in astrocyte- and microglia-enriched cultures. Data for multiple variable comparisons were analyzed by a one-way ANOVA followed by a Newman-keuls' test. Aβ42 induced a low inflammation without accumulation of acidic vesicles contrary to moderate or severe inflammation indu...Continue Reading

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Citations

Aug 28, 2014·Journal of Neuroinflammation·Arnaud FrançoisGuylène Page
Aug 9, 2015·Neuroscience Bulletin·Peizhou Liang, Weidong Le
Aug 9, 2015·Neuroscience Bulletin·Zheng-Qian LiXiang-Yang Guo
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Methods Mentioned

BETA
transgenic
protein assay
electrophoresis
confocal microscopy
Fluorescence
ELISA
Enzyme-linked immunosorbent assay

Software Mentioned

Imaris
GeneTools
ImageJ
Milliplex Analyst
Lyso
GraphPad
GraphPad InStat
Fluoview
GeneSnap
ID

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