Involvement of Interleukin 6 in Hepatitis B Viral Infection

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Caixia XiaMin Zheng

Abstract

Hepatitis B is a major global health problem and a potentially life-threatening liver infection caused by hepatitis B virus (HBV). Many cytokines including interleukin 6 (IL-6) have been shown to be involved in the HBV infection process. IL-6 is a typical cytokine made up of 184 amino acids, and the gene is located in chromosome 7p21. For healthy people, serum IL-6 levels are usually too low to be detected. However, dysregulated synthesis of IL-6 has been discovered in chronic inflammatory diseases such as hepatitis B, Crohn's disease and rheumatoid arthritis. IL-6 also plays an important role in HBV replication and in the development of hepatitis B disease. This review aims to present the latest discoveries concerning the role of IL-6 in hepatitis B disease progression, and HBV entry and replication, and evaluate polymorphisms that are associated with the development of hepatitis B disease.

Citations

Aug 17, 2017·Canadian Journal of Physiology and Pharmacology·Samir A E BashandyEnayat A Omara
Aug 1, 2019·Current Drug Targets·Bing-Yi ZhangXiao-Ping Yu
Aug 27, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jianghong ChengZhongxian Lu
May 28, 2019·Journal of Clinical Laboratory Analysis·Yan GongXiaopeng Yuan
Feb 12, 2020·ACG Case Reports Journal·Milan J SonneveldR A de Man
Jan 27, 2021·International Journal of Molecular Sciences·Sidney IrianaNeelam Sharma-Walia
Dec 23, 2019·Journal of Molecular Cell Biology·Xiaoqing ZhaoHua Tang
Jun 3, 2021·International Journal of Molecular Sciences·Arshi KhanamShyam Kottilil

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