Involvement of interleukin-8 in dialysis-related arthritis

Kidney International
F TakayamaT Niwa

Abstract

To elucidate the role of interleukin (IL)-8, a chemotactic factor for neutrophils, in dialysis-related arthritis (DRA) of patients on long-term hemodialysis, the concentration of IL-8 was measured in the synovial fluids of DRA patients with acute arthralgia and joint swelling, and was compared with those in patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA). We noted a marked elevation of IL-8 in the joint fluids of patients with DRA and RA as compared with OA. Furthermore, to determine the role of IL-8 in synovitis, we examined the in vivo effect of intra-articular injection of human recombinant IL-8 on leukocyte infiltration into the joint space of rabbits. A single injection of IL-8 to the joints of rabbits induced rapid infiltration of neutrophils into the joint space and synovial tissues, which reached a maximum in four hours. The oral administration of indometacin farnesil (a prodrug that is converted to indomethacin after intestinal absorption) before the injection of IL-8 alleviated the infiltration of neutrophils. When human synovial cells were incubated with tumor necrosis factor (TNF)-alpha, the expression of IL-8 mRNA and IL-8 production in the cultured synovial cells were increased. The T...Continue Reading

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Citations

Feb 13, 2001·Kidney International. Supplement·J Floege, M Ketteler
Aug 17, 2005·Veterinary Immunology and Immunopathology·T de BruinE Cox
Jan 24, 2007·Bioorganic & Medicinal Chemistry Letters·Brent W McClelandJakob Busch-Petersen
Aug 29, 2006·Bioorganic & Medicinal Chemistry Letters·Hong NieJakob Busch-Petersen

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