Involvement of ion channels and transporters in carcinoma angiogenesis and metastasis

American Journal of Physiology. Cell Physiology
Sonia Martial

Abstract

Angiogenesis is a finely tuned process, which is the result of the equilibrium between pro- and antiangiogenic factors. In solid tumor angiogenesis, the balance is highly in favor of the production of new, but poorly functional blood vessels, initially intended to provide growing tumors with nutrients and oxygen. Among the numerous proteins involved in tumor development, several types of ion channels are overexpressed in tumor cells, as well as in stromal and endothelial cells. Ion channels thus actively participate in the different hallmarks of cancer, especially in tumor angiogenesis and metastasis. Indeed, from their strategic localization in the plasma membrane, ion channels are key operators of cell signaling, as they sense and respond to environmental changes. This review aims to decipher how ion channels of different families are intricately involved in the fundamental angiogenesis and metastasis hallmarks, which lead from a nascent tumor to systemic dissemination. An overview of the possible use of ion channels as therapeutic targets will also be given, showing that ion channel inhibitors or specific antibodies may provide effective tools, in the near future, in the treatment of carcinomas.

References

Nov 18, 1971·The New England Journal of Medicine·J Folkman
Feb 1, 1995·Trends in Pharmacological Sciences·T P FanR Bicknell
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·S P Zamora-LeónJ C Vera
Apr 26, 1996·Neuroscience Letters·U IssbernerK H Steen
Oct 1, 1996·General Pharmacology·B NiliusG Droogmans
May 9, 1997·The Journal of Biological Chemistry·S M ValenzuelaS N Breit
Jan 1, 1997·Progress in Biophysics and Molecular Biology·B NiliusG Droogmans
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·S HiratsukaM Shibuya
Jan 14, 1999·The American Journal of Physiology·P M ChethamT Stevens
Oct 12, 1999·The American Journal of Physiology·X Wang, C van Breemen
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 26, 2000·Carcinogenesis·R S Kerbel
Apr 7, 2000·The American Journal of Pathology·H HashizumeD M McDonald
Jun 24, 2000·Annals of the New York Academy of Sciences·G PagèsJ Pouysségur
Sep 7, 2000·General Pharmacology·V G ManolopoulosB Nilius
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Jan 9, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T J PooleC M Cox
Aug 3, 2001·The Journal of Biological Chemistry·R C Elble, B U Pauli
Oct 3, 2001·Physiological Reviews·B Nilius, G Droogmans
Nov 15, 2001·The EMBO Journal·M KimA Surprenant
Mar 15, 2002·The Journal of Biological Chemistry·Garth A M SmithLyanne C Schlichter
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Apr 10, 2002·American Journal of Physiology. Cell Physiology·Michael Papetti, Ira M Herman
May 29, 2002·Nuclear Medicine and Biology·Raya S BrownRichard L Wahl
Jan 16, 2003·Cell·Barry Lubarsky, Mark A Krasnow
Mar 28, 2003·Neoplasia : an International Journal for Oncology Research·Paul A Schornack, Robert J Gillies
May 6, 2003·The Journal of Pharmacology and Experimental Therapeutics·Teruo Hayashi, Tsung-Ping Su
Jun 18, 2003·The Journal of Cell Biology·Holger GerhardtChrister Betsholtz
Aug 12, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ivana FantozziJason X-J Yuan
Oct 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·T M PocockD O Bates
Mar 24, 2004·Critical Reviews in Oncology/hematology·Myriam PolettePhilippe Birembaut
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sanae NakajimaMasayuki Imamura
Jul 16, 2004·Seminars in Radiation Oncology·Peter Vaupel
Jul 28, 2004·The Journal of Pharmacology and Experimental Therapeutics·Adrien RenaudoOlivier Soriani
Aug 4, 2004·Cancer Research·Ebru AydarMustafa B A Djamgoz
Sep 7, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Biman C PariaChinnaswamy Tiruppathi
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francesco TurturroTomas Welbourne
Nov 2, 2004·Nature Reviews. Cancer·Robert A Gatenby, Robert J Gillies

❮ Previous
Next ❯

Citations

Oct 8, 2016·Journal of Translational Medicine·Antonella BiasiottaAntonio Facchiano
Nov 12, 2016·American Journal of Physiology. Cell Physiology·Abdullah Al MamunMotohiko Sato
Aug 6, 2019·The FEBS Journal·Mariana P StellingNicholas P Farrell
Nov 16, 2019·Signal Transduction and Targeted Therapy·Yang LiWeibing Yang
Aug 9, 2020·Frontiers in Physiology·Eszter BecskeháziViktória Venglovecz
Apr 8, 2020·Future Science OA·Nihat Dilsiz
Oct 14, 2020·European Journal of Medicinal Chemistry·Alicia BauduinPaul-Alain Jaffrès
Nov 13, 2020·Signal Transduction and Targeted Therapy·Yang LiWeibing Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Related Papers

Expert Review of Anticancer Therapy
Roy L Pañares, Agustin A Garcia
Current Opinion in Obstetrics & Gynecology
Verena Bossung, Nadia Harbeck
Current Pharmaceutical Design
Daniela SiaAugusto Villanueva
Current Cancer Drug Targets
Denis Mottet, Vincent Castronovo
World Journal of Hepatology
Andreas PircherJoachim Drevs
© 2022 Meta ULC. All rights reserved