Involvement of JNK in the regulation of autophagic cell death

Oncogene
S ShimizuY Tsujimoto

Abstract

Programmed cell death is a crucial process in the normal development and physiology of metazoans, and it can be divided into several categories that include type I death (apoptosis) and type II death (autophagic cell death). The Bcl-2 family proteins are well-characterized regulators of apoptosis, among which multidomain pro-apoptotic members (such as Bax and Bak) function as a mitochondrial gateway at which various apoptotic signals converge. Although embryonic fibroblasts from Bax/Bak double-knockout (DKO) mice are resistant to apoptosis, we have previously reported that these cells still die by autophagy in response to various death stimuli. In this study, we found that jun N-terminal kinase (JNK) was activated in etoposide- and staurosporine-treated, but not serum-starved, Bax/Bak DKO cells, and that autophagic cell death was suppressed by the addition of a JNK inhibitor and by a dominant-negative mutant of JNK. Studies with sek1(-/-)mkk7(-/-) cells revealed that disruption of JNK prevented the induction of autophagic cell death. Co-activation of JNK and autophagy induced autophagic cell death. Activation of JNK occurred downstream of the induction of autophagy, and was dependent on the autophagic process. These results ind...Continue Reading

References

May 2, 1997·The Journal of Biological Chemistry·T ItoW S May
Jul 4, 1997·The Journal of Biological Chemistry·J ParkE J Choi
Mar 27, 2001·Nature Reviews. Molecular Cell Biology·Y Ohsumi
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·Eric H Baehrecke
Feb 11, 2003·Cell Structure and Function·Noboru MizushimaTamotsu Yoshimori
Oct 31, 2003·The Journal of Biological Chemistry·Gen NishitaiToshiaki Katada
Nov 5, 2004·Nature·Akiko KumaNoboru Mizushima
Nov 24, 2004·Nature Cell Biology·Shigeomi ShimizuYoshihide Tsujimoto
Jan 20, 2005·Molecular and Cellular Biology·Patricia BoyaGuido Kroemer
Apr 28, 2005·Current Biology : CB·Daniel J Klionsky
Oct 4, 2005·The Journal of Clinical Investigation·Beth Levine, Junying Yuan
Dec 13, 2005·Cell Death and Differentiation·H NakanoK Okumura
Mar 2, 2006·Molecular Cell·Juan-Jose VenturaRoger J Davis
Mar 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Li YuMichael Lenardo
Jun 24, 2008·Molecular Cell·Yongjie WeiBeth Levine
Sep 18, 2008·Biochemical and Biophysical Research Communications·Yan ChengTakashi Ikejima

❮ Previous
Next ❯

Citations

Aug 29, 2013·Archives of Toxicology·Frank Thévenod, Wing-Kee Lee
Dec 16, 2011·Apoptosis : an International Journal on Programmed Cell Death·Haitao ZhangPaul B S Lai
Sep 13, 2011·Cell Biology and Toxicology·Ji Hye HaDeok Ryong Kim
Nov 5, 2011·Cell Death and Differentiation·D DentonS Kumar
Nov 23, 2012·Cell Death & Disease·M RacitiL Di Renzo
Feb 18, 2011·Genes & Development·Ping XuRoger J Davis
Apr 13, 2012·Journal of Signal Transduction·Tokiwa YamasakiHiroshi Nishina
Sep 29, 2011·Molecular Cancer Research : MCR·Yong QinElizabeth A Grimm
Dec 29, 2010·Journal of Cell Science·Yongqiang Chen, Daniel J Klionsky
Feb 26, 2014·International Journal of Molecular Sciences·Shigeomi ShimizuSatoko Arakawa
Feb 7, 2014·Rheumatology·Chao ShenXiao-Dong Chen
Nov 1, 2011·Annual Review of Physiology·Stefan W RyterAugustine M K Choi
Aug 27, 2010·Seminars in Immunopathology·Chloe Burman, Nicholas T Ktistakis
Oct 20, 2015·Critical Reviews in Clinical Laboratory Sciences·Katie Meehan, Laura J Vella
Oct 7, 2010·Expert Review of Respiratory Medicine·Stefan W RyterAugustine Mk Choi
Feb 15, 2012·Acta Oncologica·Yoshihide Tsujimoto
Oct 26, 2010·Seminars in Cancer Biology·Lihua MinLijian Hui
Aug 25, 2010·Cancer Letters·Tom VerfailliePatrizia Agostinis
Jul 24, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Kai LiuNing Li
Sep 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Man WuHongxi Xu
Feb 11, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Abhishek D GargPatrizia Agostinis
Dec 24, 2010·Cancer Biology & Therapy·Paola Maycotte, Andrew Thorburn
Mar 30, 2013·Biochemical and Biophysical Research Communications·Yoshiyuki Ishii
Sep 27, 2014·Cell Death and Differentiation·Y Liu, B Levine
Oct 27, 2016·Journal of Cellular and Molecular Medicine·Dong YanMacus Tien Kuo
Feb 23, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H WangY J Qiao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms