Involvement of L3T4+, LYT2.2+ T cell subsets and non-T cells in the resistance of mice against Trypanosoma cruzi infection

International Journal for Parasitology
M RottenbergE L Segura

Abstract

Cellular populations involved in resistance against T. cruzi infection were characterized from mice chronically infected with the parasite. Mice transfused with spleen cells (SC), nylon-wool-non-adherent spleen cells (NWNA) or sera from mice chronically infected with T. cruzi, showed an enhanced resistance against challenge with the parasite. The protective activity of NWNA but not of SC was completely abrogated by treatment with anti-Thy1.2 monoclonal antibodies (mAb) and complement (C). Pretreatment of NWNA cells from chronically infected mice with either anti-L3T4 or anti-Lyt 2.2 mAb partially reduced the transfer of resistance. When both L3T4+ and Lyt2.2+ cells were depleted from NWNA populations, transfer of resistance was abolished. These results appear to indicate that L3T4+, Lyt2.2+ T cell subsets and non-T cells are involved in the immunity to T. cruzi.

References


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Citations

Aug 1, 1992·Scandinavian Journal of Immunology·M E RottenbergA Orn
Jul 8, 2009·PLoS Neglected Tropical Diseases·Juliana de MeisWilson Savino
Jul 20, 2007·Scandinavian Journal of Immunology·E V Acosta RodriguezA Gruppi
Dec 29, 2012·PLoS Neglected Tropical Diseases·Lívia Almeida UeharaClaudia Masini d'Avila-Levy
Oct 8, 2013·PLoS Neglected Tropical Diseases·Virginia M GonçalvesKarina R Bortoluci
Aug 1, 1991·Experimental Parasitology·M E RottenbergE L Segura
Sep 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C RadzikowskiJ Zeuthen

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