Involvement of leptin in hypophagia induced by the serotonin precursor 5-hydroxytryptophan (5-HTP) in mice

Biological & Pharmaceutical Bulletin
Jun YamadaM Ujikawa

Abstract

We previously demonstrated that a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. It was reported that administration of 5-HTP elicits hypophagia in rodents and humans. In the present study, we examined involvement of leptin in 5-HTP-elicited decreases in the milk intake of fasted mice. Serum leptin levels increased with increases in milk intake in mice, while 5-HTP strongly decreased milk intake in fasted mice compared to that in the control group. Serum leptin levels in fasted mice treated with 5-HTP were similar to those control mice after milk intake. As leptin is a powerful anorectic signal, 5-HTP-induced anorexia may be mediated by facilitation of leptin secretion.

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Citations

Sep 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M RondanelliA Opizzi
Sep 25, 2010·Neuroscience Letters·Guadalupe García-AlcocerRicardo Miledi
Sep 15, 2014·Behavioural Brain Research·Jörg-Peter Voigt, Heidrun Fink
Nov 26, 2010·Journal of Clinical Psychopharmacology·Jochem G GregoorJan van der Weide
Mar 5, 2021·Behavioural Pharmacology·Ernesto Limón-BernalHéctor I Rocha-González

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