Involvement of Leukotriene B4 Released from Keratinocytes in Itch-associated Response to Intradermal Interleukin-31 in Mice

Acta Dermato-venereologica
Tsugunobu AndohYasushi Kuraishi

Abstract

A recent study suggests that interleukin-31 (IL-31) exerts its effect via indirect mechanisms rather than through direct stimulation of cutaneous nerves. However, the underlying peripheral mechanisms of IL-31-induced itch in the skin remain unclear. Therefore, the present study investigated the peripheral mechanisms underlying IL-31-induced itch in mice. IL-31-induced itch-related response was inhibited by anti-allergic drugs (tranilast and azelastine), but not by an H1 histamine receptor antagonist (terfenadine). Furthermore, a 5-lipoxygenase inhibitor (zileuton), but not a cyclooxygenase inhibitor (indomethacin), and a leuko-triene B4 (LTB4) receptor antagonist (CMHVA) attenuated the action of IL-31. IL-31 receptor-immunoreactivity was observed in the epidermis and primary sensory neurones. IL-31 receptor mRNA was expressed in mouse keratinocytes and dorsal root ganglia neurones. IL-31 increased the production of LTB4 in mouse keratinocytes. These results suggest that IL-31 elicits itch not only through direct action on primary sensory neurones, but also by inducing LTB4 production in keratinocytes.

Citations

Feb 25, 2018·Pharmacological Reports : PR·Tsugunobu AndohDaisuke Uta
Dec 24, 2019·Physiological Reviews·Ferda Cevikbas, Ethan A Lerner
Oct 18, 2019·Frontiers in Cellular Neuroscience·Hanna Siiskonen, Ilkka Harvima
Feb 5, 2019·International Immunology·Tetsuya Honda, Kenji Kabashima
Feb 26, 2021·Allergy·Angeliki DatsiJoerg Buddenkotte
Jun 15, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Toshiaki HirakataTakehiko Yokomizo

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