Involvement of liver-associated immunity in hepatic metastasis formation

The Journal of Surgical Research
K OkunoM Yasutomi

Abstract

Hepatic metastasis formation and prevention were studied from the viewpoint of liver-associated immunity. RCN-9, a colonic cancer cell line derived from Fischer rats, and its subclone RCN-H4, in which the cancer is highly metastatic to the liver, were used. Fischer rats that were inoculated with parent RCN-9 colonic cancer cells (5 x 10(6)) via the portal vein showed liver metastasis in less than 60% of the animals. In contrast, all rats (100%) that received RCN-H4 produced multiple liver metastases. To investigate the difference of hepatic metastasis formation, we assessed the susceptibility of both cell lines against hepatic sinusoidal lymphocytes (HSL) by 51Cr-release assay, and the expression of MHC class I and class II of both cell lines by flow cytometry. In addition, we examined whether activation of HSL by interleukin-12 (IL-12) can prevent liver metastasis of highly metastatic clone RCN-H4. The RCN-H4 clone showed decreased susceptibility to lysis by natural cytotoxic cells in HSL. This decrease in cell susceptibility was attributable to an increase in cell surface expression of MHC class I antigen. Administration of IL-12, a potent NK/CTL stimulatory cytokine, augmented the cytotoxic activity against the RCN-H4 clone ...Continue Reading

References

Aug 24, 1985·British Medical Journal·D Francis, R Judson
Jan 1, 1984·Cancer Metastasis Reviews·D A AugustP H Sugarbaker
Mar 1, 1994·Stem Cells·S F WolfJ Sypek
Oct 1, 1994·Immunology Today·G Trinchieri, P Scott
Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately

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Citations

Mar 11, 2011·World Journal of Gastroenterology : WJG·Hai-Bo QiuRui-Hua Xu
Jul 18, 2002·The Journal of Surgical Research·Koji DoiKuniyoshi Tanaka
Jun 8, 1999·The Journal of Surgical Research·C M VolpeS A Cohen
Jan 28, 2006·World Journal of Gastroenterology : WJG·Masanao KurataNobuhiro Ohkohchi
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keith S BahjatMartin A Giedlin
Sep 19, 2014·International Journal of Oncology·Hideki MatsumuraNobuhiro Ohkohchi

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