PMID: 9418248Jan 7, 1998Paper

Involvement of MAP-kinases and -phosphatases in uptake and intracellular replication of Listeria monocytogenes in J774 macrophage cells

FEMS Microbiology Letters
S KüglerW Goebel

Abstract

In this study we show that protein tyrosine kinases and also protein tyrosine phosphatases are involved in the uptake of Listeria monocytogenes by J774 macrophages to a different extent than in the uptake of inert latex beads. In addition, protein tyrosine kinases are necessary for the intracellular growth and survival of L. monocytogenes. The expression of the MAP kinase phosphatase MKP-1, a protein tyrosine phosphatase, is induced upon infection, and phagocytosis of L. monocytogenes by J774 cells overexpressing the MKP-1 protein is reduced compared to control cells. The decreased phagocytosis of L. monocytogenes as a result of the MKP-1 overexpression in J774 macrophages suggests that the activation of the MAP kinase(s) ERK-1 and/or ERK-2 is an essential requirement for the uptake of L. monocytogenes by J774 macrophages.

References

Oct 1, 1992·Molecular Biology of the Cell·D N DrechselM W Kirschner
Nov 1, 1994·Trends in Biochemical Sciences·G DaumU R Rapp
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·W R Schwan, W Goebel
Jan 29, 1993·Cell·L L LinR J Davis
Nov 1, 1996·Science·K IretonP Cossart

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Citations

Sep 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Luisa W ChengDaniel A Portnoy
Jun 5, 2008·Journal of Cell Communication and Signaling·Himanshi NarangMalini Krishna
Jan 19, 2008·FEBS Letters·Elisabeth ElassYann Guérardel
Oct 12, 2013·Basic & Clinical Pharmacology & Toxicology·Riku Korhonen, Eeva Moilanen
Feb 17, 2015·Journal of Molecular Recognition : JMR·Rita SzabóFerenc Hudecz
Mar 24, 2006·FEMS Immunology and Medical Microbiology·Jarosław WiśniewskiJacek Bielecki
Feb 26, 2008·Molecular Immunology·Kishore V L ParsaSusheela Tridandapani
Jul 28, 2016·Seminars in Cell & Developmental Biology·Javier Pizarro-CerdáPascale Cossart
Feb 12, 2015·Trends in Cell Biology·Alice LebretonPascale Cossart
Feb 6, 2004·American Journal of Physiology. Cell Physiology·Hiroe Shiratsuchi, Marc D Basson
Jan 1, 2009·Journal of Organ Dysfunction·Yusen Liu, Thomas P Shanley

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