Involvement of microglia in early axoglial alterations of the optic nerve induced by experimental glaucoma

Journal of Neurochemistry
Melina BordoneDamián Dorfman

Abstract

Glaucoma is a leading cause of blindness, characterized by retinal ganglion cell (RGC) loss and optic nerve (ON) damage. Cumulative evidence suggests glial cell involvement in the degeneration of the ON and RGCs. We analyzed the contribution of microglial reactivity to early axoglial alterations of the ON in an induced model of ocular hypertension. For this purpose, vehicle or chondroitin sulfate (CS) were weekly injected into the eye anterior chamber from Wistar rats for different intervals. The amount of Brn3a(+) RGC significantly decreased in CS-injected eyes for 10 and 15 (but not 6) weeks. A reduction in anterograde transport of β-subunit cholera toxin was observed in the superior colliculus and the lateral geniculate nucleus contralateral to CS-injected eyes for 6 and 15 weeks. A disruption of cholera toxin β-subunit transport was observed at the proximal myelinated ON. A significant decrease in phosphorylated neurofilament heavy chain immunoreactivity, an increase in ionized calcium-binding adaptor molecule 1(+), ED1(+) (microglial markers), and glial fibrillary acidic protein (astrocytes) (+) area, and decreased luxol fast blue staining were observed in the ON at 6 and 15 weeks of ocular hypertension. Microglial reactiv...Continue Reading

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Citations

Jan 22, 2019·Investigative Ophthalmology & Visual Science·Shandiz TehraniJohn C Morrison
Oct 7, 2019·Journal of Neurochemistry·María F González FleitasRuth E Rosenstein
Jun 1, 2018·Annual Review of Vision Science·Sean M Silverman, Wai T Wong
Mar 6, 2019·Investigative Ophthalmology & Visual Science·Diana C LozanoElaine C Johnson
Sep 24, 2019·Frontiers in Neuroscience·Teresa TsaiStephanie C Joachim
Apr 21, 2020·Brain and Behavior·Chenyang HanQingcai Jiao
Jan 19, 2020·International Journal of Molecular Sciences·Pia GrotegutStephanie C Joachim
Sep 20, 2020·Journal of Lipid Research·M Victoria SimonNawajes Mandal
Dec 16, 2020·Journal of Neuroinflammation·Pia GrotegutStephanie C Joachim
Feb 9, 2021·Journal of Lipid Research·Simon M VictoriaMandal Nawajes
Aug 11, 2020·Progress in Retinal and Eye Research·Meysam YazdankhahNadezda A Stepicheva
Apr 1, 2021·Molecular Neurobiology·María F González FleitasRuth E Rosenstein
Oct 20, 2020·Progress in Retinal and Eye Research·Christophe BaudouinElisabeth M Messmer
Aug 28, 2021·Biomolecules·Sophie CoyleVictoria McGilligan

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