Involvement of miR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells

Cell Death & Disease
Lu YangShilpa Buch

Abstract

Highly conserved microRNA-9 (miR-9) has a critical role in various cellular processes including neurogenesis. However, its regulation by neurotropins that are known to mediate neurogenesis remains poorly defined. In this study, we identify platelet-derived growth factor-BB (PDGF-BB)-mediated upregulation of miR-9, which in turn downregulates its target gene monocyte chemotactic protein-induced protein 1 (MCPIP1), as a key player in modulating proliferation, neuronal differentiation as well as migration of neuronal progenitor cells (NPCs). Results indicate that miR-9-mediated NPC proliferation and neuronal differentiation involves signaling via the nuclear factor-kappa B (NF-κB) and cAMP response element-binding protein (CREB) pathways, and that NPC migration involves CREB but not the NF-κB signaling. These findings thus suggest that miR-9-mediated downregulation of MCPIP1 acts as a molecular switch regulation of neurogenesis.

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Citations

Aug 20, 2014·Cellular and Molecular Life Sciences : CMLS·Darren Ferrell, Brian Giunta
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Aug 17, 2014·Experimental Neurology·Emily Sun, Yanhong Shi
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Jul 2, 2019·Journal of Extracellular Vesicles·Ye ZengBingmei M Fu

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Methods Mentioned

BETA
transfection
nuclear translocation
PCR
transfections

Software Mentioned

TargetScan
AxioVs 40

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