Involvement of mitogen-activated protein kinases in class B scavenger receptor type I-induced phagocytosis of apoptotic cells

Experimental Cell Research
Yoichi OsadaYoshinobu Nakanishi

Abstract

Class B scavenger receptor type I (SR-BI) is a multiligand membrane protein expressed in a variety of cell types. This receptor is responsible for the incorporation of lipids from high density lipoprotein (HDL) by steroidogenic cells, as well as for the phosphatidylserine (PS)-mediated phagocytosis of apoptotic cells by some phagocytic cell types, such as testicular Sertoli cells. Although SR-BI directly binds to PS present on the surface of apoptotic cells, as to whether SR-BI transmits signals to induce engulfment has not been clear. In the present study, we examined this issue using a monoclonal antibody that neutralizes SR-BI activity and a chemical known to be an inhibitor of the SR-BI-mediated incorporation of HDL lipids. The chemical compound inhibited the incorporation of HDL lipids and PS-containing liposomes by an SR-BI-expressing culture cell line, with no effect on the binding of these targets. Similarly, the phagocytosis of PS-exposing apoptotic cells by primary cultured rat Sertoli cells was inhibited in the presence of either reagent, not at the recognition but at the engulfment step. The addition of apoptotic cells or PS-containing liposomes caused a temporal increment of the phosphorylation of all three mitogen...Continue Reading

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Citations

Jul 19, 2014·Cell Death and Differentiation·Y MurakamiJ E Coligan
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Miao YuMonty Krieger
Jan 6, 2009·Journal of Biochemistry·Yoichi OsadaAkiko Shiratsuchi
Oct 3, 2007·Immunology and Cell Biology·Akiko ShiratsuchiYoshinobu Nakanishi
Dec 25, 2007·Molecular Reproduction and Development·Kaz NagaosaYoshinobu Nakanishi
Jul 30, 2016·Journal of Alzheimer's Disease : JAD·YuHong FuWoojin Scott Kim
May 30, 2007·Journal of Lipid Research·Thomas J F NielandMonty Krieger
Sep 24, 2015·Physiological Genomics·Angie M Y ShumPatsie Polly
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ikuko WatanabeYoshinobu Nakanishi

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