PMID: 9171996Jun 1, 1997Paper

Involvement of multiple loci on chromosome 3 in renal cell cancer development

Genes, Chromosomes & Cancer
A van den Berg, C H Buys

Abstract

In renal cell carcinoma (RCC), mostly occurring as sporadic cases, the short arm of chromosome 3 is a frequent target of deletion events. Taking into account cytological classifications of RCC, the deletions appear to be characteristic of clear cell or nonpapillary RCC only. This subtype constitutes most sporadic RCC and RCC as part of the Von Hippel-Lindau disease caused by germline mutations of VHL at 3p25. In a proportion of sporadic tumours, somatic mutations of VHL occur, again only in clear cell or nonpapillary RCC. However, in a sizable proportion of sporadic clear cell RCC, VHL mutations are absent. Therefore, a role for VHL in RCC development in general seems unlikely. Familial papillary RCC is not linked to chromosome 3. A rat model of hereditary RCC, the EKER rat, is associated with a germline mutation of the rat homologue of the tuberous sclerosis gene on human chromosome 16. Analysis of allelic losses of chromosome 3 in 143 highly informative sporadic tumours published in the literature points to a small segment of 3p21.3 as a candidate tumour-suppressor region. A 2-Mb fragment containing this segment suppresses tumourigenicity when present in mouse fibrosarcoma cells. A similar effect could be attributed to the re...Continue Reading

Citations

Feb 13, 2003·Pathology Oncology Research : POR·Francesca GirolamiFrancesca Torricelli
Dec 13, 2007·International Urology and Nephrology·Sevim AkcaglarBulent Oktay
May 9, 2002·Cancer Genetics and Cytogenetics·Danielle BodmerAd Geurts van Kessel
Dec 9, 1998·Cancer Genetics and Cytogenetics·M BernuésJ Egozcue
Jan 2, 2007·BMC Genomics·Eva Darai-RamqvistMaria Kost-Alimova
Jan 30, 2007·BMC Cancer·Maria Kost-AlimovaStefan Imreh
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y ChengE J Stanbridge
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·R M GemmillH A Drabkin
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·K DreijerinkE R Zabarovsky
Jan 31, 2008·Genome Research·Eva Darai-RamqvistMaria Kost-Alimova
May 31, 2006·American Journal of Nephrology·Andreas A SkolarikosCharalambos Deliveliotis
Mar 10, 2000·International Journal of Cancer. Journal International Du Cancer·P M McLaughlinC H Buys
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Eleonora BragaEugene R Zabarovsky
Apr 3, 2001·Genes, Chromosomes & Cancer·M J EleveldA Geurts Van Kessel
Dec 5, 1998·British Journal of Urology·K SubramonianP Curley

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