Involvement of nitric oxide and cyclic GMP in rabbit urethral relaxation

European Journal of Pharmacology
S DokitaR M Weiss

Abstract

Soluble and particulate fractions from rabbit urethra converted [14C]arginine to [14C]citrulline, indicating the presence of nitric oxide synthase activity in these fractions. Both soluble and particulate nitric oxide synthase activities were NADPH dependent, and the soluble activity was Ca2+ dependent. Three nitric oxide synthase (NOS) inhibitors affected transmural nerve stimulation induced relaxation responses in the rabbit urethra and the activity of soluble nitric oxide synthase with the same rank order of potency, i.e., NG-nitro-L-arginine (NNA) > NG-methyl-L-arginine (NMA) > canavanine (CAN). The rank order of potency with respect to particulate NOS activity was CAN > NMA = NNA. The relaxation responses to electrical stimulation were accompanied by increases in cyclic GMP. These results suggest that NOS activity found in the soluble fraction of urethral homogenates produces nitric oxide that in turn increases cyclic GMP levels which mediates the relaxation responses induced by transmural nerve stimulation in the rabbit urethra.

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Citations

Mar 26, 2002·The Journal of Urology·Annette SchroderKarl-Erik Andersson
Mar 28, 1998·British Journal of Pharmacology·K WaldeckK E Andersson
Aug 28, 1998·British Journal of Pharmacology·C PinnaG Burnstock
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Jul 23, 2004·Physiological Reviews·Karl-Erik Andersson, Anders Arner
Sep 7, 2007·Neurourology and Urodynamics·Karl-Erik AnderssonPetter Hedlund
Apr 28, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Marcia A WheelerRobert M Weiss
Apr 4, 2015·International Urology and Nephrology·Alper OtunctemurEmin Ozbek
Sep 21, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Kyung K KangYoung C Kim
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Feb 11, 2020·American Journal of Physiology. Renal Physiology·Eduardo C AlexandreNaoki Yoshimura

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