PMID: 11910523Mar 23, 2002Paper

Involvement of nitric oxide in the ocular hypotensive action of nipradilol

Current Eye Research
T SugiyamaT Ikeda

Abstract

To evaluate the role of nitric oxide (NO) in the mechanism of the ocular hypotensive action of nipradilol, a beta-blocker with alpha( 1)-blocking activity. Change in intraocular pressure (IOP) of albino rabbits was measured after a single application of carboxy-PTIO (c-PTIO), an NO trapping agent. Next, IOP change was measured every hour for 5 hours after the instillation of 0.25% nipradilol into one of the eyes with and without c-PTIO pretreatment of both eyes. IOP change induced by desnitro-nipradilol was also examined. The outflow facility and uveoscleral outflow were determined by two-level constant pressure and anterior chamber perfusion methods before and at 3 hours after the application of nipradilol with and without c-PTIO pretreatment. Topical administration of c-PTIO showed no significant effect on IOP. Unilateral instillation of nipradilol reduced IOP significantly compared with control eyes with a maximum reduction of 3.6 mmHg and effect duration of 3 hours. Pretreatment with c-PTIO partially inhibited the reduction during an earlier period (1 approximately 2 hours) and completely at 3 hours. IOP change by desnitro-nipradilol was similar to that by nipradilol with c-PTIO pretreatment. Nipradilol increased both outfl...Continue Reading

References

Jan 29, 1982·Documenta Ophthalmologica. Advances in Ophthalmology·H C InnemeeP A van Zwieten

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Citations

Mar 10, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Megumi NakanishiTsunehiko Ikeda
Jan 24, 2003·Annual Review of Pharmacology and Toxicology·Claudio Napoli, Louis J Ignarro
Jan 7, 2005·Biological & Pharmaceutical Bulletin·Masahiro OrihashiIkuko Kimura
Feb 7, 2016·Experimental Eye Research·Mark JohnsonDarryl R Overby
Mar 19, 2003·British Journal of Pharmacology·Jesus PintorAssumpta Peral
Jan 17, 2013·Japanese Journal of Ophthalmology·Chihiro Mayama, Makoto Araie
Dec 1, 2020·Progress in Retinal and Eye Research·Ester Reina-TorresW Daniel Stamer
Dec 4, 2003·Pharmacology & Therapeutics·Noboru Toda

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