Involvement of nitroxidergic and noradrenergic nerves in the relaxation of dog and monkey temporal veins

Journal of Cardiovascular Pharmacology
N TodaT Okamura

Abstract

We determined involvement of nitric oxide (NO) derived from perivascular nerve in venous relaxation. In helical strips of dog superficial temporal veins contracted with prostaglandin F2 alpha (PGF2 alpha) nicotine produced a contraction, which was reversed to a relaxation by prazosin. The relaxation was partially attenuated by timolol or metoprolol. The residual relaxation was not influenced by treatment with atropine or indomethacin and by endothelium denudation but was abolished by NG-nitro-L-arginine (L-NA), a NO synthase inhibitor, and hexamethonium. L- but not D-arginine reversed the inhibition induced by L-NA. Relaxations induced by NO were not influenced by L-NA. Similar results were also obtained in relaxations induced by transmural electrical stimulation that were sensitive to tetrodotoxin (TTX). In the monkey venous strips, relaxations induced by nicotine under treatment with prazosin were reduced by timolol. The relaxation observed with combined treatment with alpha- and beta-antagonists was abolished by L-NA, and L-arginine restored the response. The presence of nerve fibers containing NO synthase immunoreactivity or NADPH diaphorase in the adventitia of dog and monkey veins was determined histologically. The findin...Continue Reading

Citations

Apr 24, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anna P ZiganshinaAyrat U Ziganshin
Apr 12, 2005·Journal of Cardiovascular Pharmacology·Salma Toma HannaRui Wang
Apr 4, 2007·The Journal of Pharmacology and Experimental Therapeutics·Daliao XiaoLubo Zhang
Oct 28, 2006·The Journal of Pharmacology and Experimental Therapeutics·DaLiao XiaoLubo Zhang
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura

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