Involvement of NMDA receptors, nitric oxide and GABA in rostral ventrolateral medulla in acute ethanol-induced cardiovascular responses in rats

Alcoholism, Clinical and Experimental Research
Hsuan LoChih-Chia Lai

Abstract

Consumption of ethanol (alcohol) has many effects on physiological functions, particularly those in the central nervous system (CNS) and cardiovascular system. Acute excessive intake of ethanol (alcohol intoxication) may cause hypotension and tachycardia. In this study, we examined the mechanistic involvement of glutamatergic NMDA receptors, nitric oxide (NO) andγ-aminobutyric acid (GABA) pathways in the CNS in acute ethanol-induced cardiovascular effects. Ethanol was administered by intraperitoneal (IP) injection in Sprague Dawley (SD) rats. The blood pressure (BP) and heart rate (HR) were measured in conscious and in urethane-anesthetized rats. Inhibitors were applied by intracerebroventricular (ICV) injection or by microinjection into rostral ventrolateral medulla (RVLM). Microdialysis was used to determine the level of glutamate, NO, and GABA in the RVLM. IP injection of ethanol (3.2 g/kg) caused a significant decrease in BP in conscious and anesthetized rats and a late increase in HR in conscious rats. The cardiovascular effects of ethanol were significantly attenuated by ICV or by RVLM post-treatment with ketamine (an NMDA receptor antagonist), L-NNA (a NO synthase inhibitor), or bicuculline (a GABA receptor antagonist). ...Continue Reading

References

Sep 7, 1991·BMJ : British Medical Journal·M Marmot, E Brunner
Oct 1, 1988·Journal of the Autonomic Nervous System·R A DampneyE Tan
Feb 1, 1997·Alcoholism, Clinical and Experimental Research·P J ConrodS Mankowski
Jul 14, 1997·Journal of the Autonomic Nervous System·H RaoJ P Kessler
Dec 11, 1997·The New England Journal of Medicine·M J ThunR Doll
Mar 25, 1999·American Journal of Hypertension·G A RositoB B Duncan
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·D C HattonJ K Belknap
Feb 24, 2001·Clinical and Experimental Pharmacology & Physiology·S Y ChenC Y Chai
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marisa RobertoGeorge R Siggins
May 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa A Fleegal, Colin Sumners
Nov 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alan F Sved
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Roberto I MelendezPeter W Kalivas
Dec 13, 2006·Archives of Internal Medicine·Augusto Di CastelnuovoGiovanni de Gaetano
Jun 21, 2007·Anesthesia and Analgesia·Chih-Chia LaiHsun-Husn Lin
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Paul M PilowskyAnn K Goodchild
Jun 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michal BajoMarisa Roberto
Jul 1, 2008·The European Journal of Neuroscience·John Garthwaite
Jul 29, 2008·Alcoholism, Clinical and Experimental Research·Robert C Ristuccia, Linda P Spear
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eszter SzabaditsGábor Nyiri
Oct 25, 2011·Alcoholism, Clinical and Experimental Research·Zheng-Ming DingWilliam J McBride
Sep 14, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Keisuke ShinoharaKenji Sunagawa
Aug 3, 2013·Alcoholism, Clinical and Experimental Research·Mahmoud M El-MasAbdel A Abdel-Rahman
Aug 3, 2013·Alcoholism, Clinical and Experimental Research·M Saeed Dar
Sep 27, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William C GriffinHoward C Becker
Jul 6, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Andrew D ChappQing-Hui Chen
Mar 31, 2015·Nitric Oxide : Biology and Chemistry·Niall FinnertyErik Pålsson

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