Abstract
Oleoylethanolamide (OEA) is an endocannabinoid analogy that belongs to a family of endogenous acylethanolamides. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of mental disorder-related behaviors. In the present study, we investigated the antidepressant- like potential of OEA in mice in comparison with clomipramine (Cp). 50 mice were randomly divided into 5 groups, and treated with a vehicle (0.3% methyl cellulose, 20 mL/kg, p.o.), OEA (2.5, 5-10mg/kg, p.o.), or Cp (10mg/kg, p.o.) for 7 days. The immobility was used to evaluate depressive-like behaviors in tail suspension test (TST) and forced swimming test (FST). ELISA detected changes in cerebral noradrenaline (NE) and serotonin (5-HT) levels. Likewise, in the drug-induced model of depression, OEA was given once daily at 10mg/kg (p.o.) for 7 consecutive days. Then, the mice received reserpine (4 mg/kg, i.p.) and the rectal temperature was measured at different time points. Consequently, head twitch behavior induced by intraperitoneal injection of 5-hydroxy-tryptophan (5-HTP; 300 mg/kg) were determined. The experimental data showed that OEA (2.5-10mg/kg) treatment significantly decreased the immobility as c...Continue Reading
References
Jan 1, 1985·Psychopharmacology·L SteruP Simon
Apr 4, 2002·Neuroreport·Andrea D E ZomkowskiAna Lúcia S Rodrigues
May 15, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ricardo W BinfaréAna Lúcia S Rodrigues
May 16, 2009·Current Pharmaceutical Design·Francis Rodriguez BambicoGabriella Gobbi
Sep 8, 2009·Trends in Pharmacological Sciences·Matthew N HillGabriella Gobbi
Oct 21, 2009·CNS & Neurological Disorders Drug Targets·Matthew N Hill, Boris B Gorzalka
Apr 1, 2010·Experimental Neurology·M T ViscomiM Molinari
Apr 1, 2010·Experimental Neurology·Daniela ParolaroTiziana Rubino
Jun 15, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Fan XuBoyang Yu
Aug 23, 2011·Pharmacological Reports : PR·Hai-Ling YuXian-Yu Sun
Feb 14, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ryan J McLaughlinBoris B Gorzalka
Apr 7, 2012·Neuropharmacology·Yu ZhouXin Jin
Nov 21, 2012·Addiction Biology·Ainhoa BilbaoFernando Rodríguez de Fonseca
Sep 10, 2013·Indian Journal of Pharmacology·Shvetank BhattAnkur Kumar Jindal
Sep 21, 2013·Ayu·M ShreevathsaRambabu Dwivedi
Oct 16, 2013·Journal of Affective Disorders·Vipin Arora, Kanwaljit Chopra
Dec 7, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Alline C CamposFrancisco S Guimarães
Mar 22, 2014·Neurotoxicity Research·Irena SmagaMałgorzata Filip
Jun 10, 2014·Pharmacological Reports : PR·Sylwia WośkoEwa Poleszak
Citations
Dec 15, 2015·Physiology & Behavior·Maria J van KootenDana M Small
Dec 9, 2015·Neurotoxicology·Russell L CarrCarole A Nail
Oct 22, 2016·Journal of Neurochemistry·Silvana GaetaniMaria Beatrice Passani
Jan 14, 2017·Neuroscience Letters·Miao-Miao LiHai-Ling Yu
Feb 23, 2018·Metabolic Brain Disease·Jun-Ming WangGui-Fang Wang
Mar 24, 2018·Behavioural Pharmacology·John HamiltonPanayotis K Thanos
Aug 22, 2017·Frontiers in Endocrinology·Undurti N Das
Nov 15, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gilliard LachJohn F Cryan
Jun 3, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Richard M O'Connor
May 1, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adele RomanoSilvana Gaetani
May 22, 2020·Frontiers in Behavioral Neuroscience·Luisa RochaFrancia Carmona-Cruz
Aug 17, 2021·The European Journal of Neuroscience·Eric Murillo-RodríguezPablo Torterolo