Involvement of opioid and GABA systems in the ventrolateral periaqueductal gray on analgesia associated with tonic immobility

Pharmacology, Biochemistry, and Behavior
Abraham Miranda-PáezEduardo Ramírez-San Juan

Abstract

Ventrolateral periaqueductal gray (VL-PAG) contains key neuronal circuits related to the analgesic effect involved in integrated defensive behaviors such as immobility response (IR). The latter is characterized by a reversible state of motor inhibition that can be elicited in rats under several conditions including restriction of movements (tonic immobility: TI). It is known that IR-induced analgesia can be elicited by manipulations or drugs acting on the central nervous system (CNS) at different levels. The aim of this study was to assess the role of the opioid and the GABA systems in TI-elicited analgesia. After inducing TI in naïve rats by neck clamping, the analgesic effect was evaluated by the tail-flick (TF) test. Compared to the control group, rats with TI had increased TF latency evidencing an analgesic effect. An opioid receptor agonist and antagonist were injected systemically, as well as microinjected locally in VL-PAG, as well as GABAA receptor agonist and antagonist were microinjected into VL-PAG. Under both injection schemes, morphine increased TF latency and TI duration, while naloxone blocked TI-induced analgesia. Muscimol reduced TF latency and TI duration while bicuculline increased TF latency but not TI durat...Continue Reading

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Citations

Jun 30, 2019·Journal of Neuroscience Research·Braeden A TerpouRuth A Lanius
Dec 1, 2019·The Journal of Pain : Official Journal of the American Pain Society·Herick Ulisses de OliveiraGiovane Galdino
Dec 6, 2019·Peptides·Richard J Bodnar
Feb 13, 2019·Neuroscience Letters·Bruna B de PaulaChristie R A Leite-Panissi
May 6, 2021·Acta Neurobiologiae Experimentalis·Priscila Vázquez-LeónAbraham Miranda-Páez
Jul 25, 2021·Neuroscience Bulletin·Priscila Vázquez-LeónBruno A Marichal-Cancino

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