Involvement of Opioid System, TRPM8, and ASIC Receptors in Antinociceptive Effect of Arrabidaea brachypoda (DC) Bureau

International Journal of Molecular Sciences
Vinícius Peixoto RodriguesClélia Akiko Hiruma-Lima

Abstract

Arrabidaea brachypoda (DC) Bureau is a medicinal plant found in Brazil. Known as "cipó-una", it is popularly used as a natural therapeutic agent against pain and inflammation. This study evaluated the chemical composition and antinociceptive activity of the dichloromethane fraction from the roots of A. brachypoda (DEAB) and its mechanism of action. The chemical composition was characterized by high-performance liquid chromatography, and this fraction is composed only of dimeric flavonoids. The antinociceptive effect was evaluated in formalin and hot plate tests after oral administration (10-100 mg/kg) in male Swiss mice. We also investigated the involvement of TRPV1 (transient receptor potential vanilloid 1), TRPA1 (transient receptor potential ankyrin 1), TRPM8 (transient receptor potential melastatin 8), and ASIC (acid-sensing ion channel), as well as the opioidergic, glutamatergic, and supraspinal pathways. Moreover, the nociceptive response was reduced (30 mg/kg) in the early and late phase of the formalin test. DEAB activity appears to involve the opioid system, TRPM8, and ASIC receptors, clearly showing that the DEAB alleviates acute pain in mice and suggesting the involvement of the TRPM8 and ASIC receptors and the opioi...Continue Reading

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Citations

Jun 28, 2020·Journal of Toxicology and Environmental Health. Part a·Higor Lopes NunesIlce Mara de Syllos Cólus
Aug 30, 2020·International Journal of Molecular Sciences·Daniel A Jacobo-Velázquez, Luis Cisneros-Zevallos
Dec 6, 2019·Peptides·Richard J Bodnar
Nov 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carlota SalgadoEric Allémann

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Methods Mentioned

BETA
sedation

Software Mentioned

DEAB

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