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Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells

Toxicon : Official Journal of the International Society on Toxinology

Feb 11, 2010

Ying-Jung ChenLong-Sen Chang

Abstract

CMS-9, a phospholipase A(2) (PLA(2)) isolated from Naja nigricollis venom, induced apoptosis of human leukemia K562 cells, characterized by mitochondrial depolarization, modulation of Bcl-2 family members, cytochrome c release and activation of caspases 9 and 3. Moreover, an increase in...read more

Mentioned in this Paper

Flow Cytometry
Biochemical Pathway
Necrosis
Ethanol
Naja naja atra
Annexin A5
Glycerin
Dimethyl Sulfoxide
Ethanol Measurement
Apoptosis, Intrinsic Pathway
Paper Details
References
  • References20
  • Citations16
12
  • References20
  • Citations16
12

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Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells

Toxicon : Official Journal of the International Society on Toxinology

Feb 11, 2010

Ying-Jung ChenLong-Sen Chang

PMID: 20144638

DOI: 10.1016/j.toxicon.2010.01.024

Abstract

CMS-9, a phospholipase A(2) (PLA(2)) isolated from Naja nigricollis venom, induced apoptosis of human leukemia K562 cells, characterized by mitochondrial depolarization, modulation of Bcl-2 family members, cytochrome c release and activation of caspases 9 and 3. Moreover, an increase in...read more

Mentioned in this Paper

Flow Cytometry
Biochemical Pathway
Necrosis
Ethanol
Naja naja atra
Annexin A5
Glycerin
Dimethyl Sulfoxide
Ethanol Measurement
Apoptosis, Intrinsic Pathway

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Lipids & Membrane Homeostasis

The cellular membrane is composed of diverse lipid molecules that help maintain membrane integrity and homeostasis. Discover the latest research on Lipids & Membrane Homeostasis

Lipid Signaling in Disease

Lipids are water-insoluble molecules that make up the cell membrane and play an essential role in functioning as second messengers, hormones, and in signal transduction. Here is the latest research on lipid signaling in human diseases.

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Paper Details
References
  • References20
  • Citations16
12
  • References20
  • Citations16
12
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