Involvement of p38 signaling pathway in interferon-alpha-mediated antiviral activity toward hepatitis C virus

Biochemical and Biophysical Research Communications
Hisashi IshidaNorio Hayashi

Abstract

We studied the involvement of the p38 signaling pathway in the interferon (IFN)-alpha-mediated antiviral activity toward hepatitis C virus (HCV) using HCV subgenomic replicon cells. When the cells were treated with IFN-alpha in the presence of p38 inhibitor, the suppressive effect of IFN-alpha on replicon RNA was reduced. Inhibition of p38 had almost no influence on phosphorylation of signal transducer and activator transcription factor 1 (STAT1) and interferon stimulatory response element-dependent gene expression after IFN-alpha treatment. This indicates that the anti-HCV activity through p38 may be independent of the Janus kinase-STAT pathway. Treatment with the inhibitor of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) showed the same level of reduction in the IFN-alpha-mediated anti-HCV activity as that with the p38 inhibitor. Thus, MK2 may also be responsible for the anti-HCV activity through p38. In conclusion, the p38-MK2 signaling pathway may be substantially involved in the IFN-alpha-mediated anti-HCV activity.

References

Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M MiyazakiM Namba
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KiyosawaR H Purcell
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L B Seeff
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
Oct 9, 1999·The Journal of Biological Chemistry·S UddinL C Platanias
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Feb 13, 2002·The Journal of Biological Chemistry·Shahab UddinLeonidas C Platanias
Apr 6, 2002·Bioorganic & Medicinal Chemistry Letters·James E ThompsonJulie A DeMartino
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
May 3, 2003·Pharmacology & Therapeutics·Leonidas C Platanias
Oct 28, 2003·The Journal of Biological Chemistry·Yongzhong LiLeonidas C Platanias

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Citations

Jun 29, 2013·Biochemical and Biophysical Research Communications·Hisashi IshidaTetsuo Takehara
May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Jan 10, 2012·Nature Reviews. Immunology·José M González-NavajasEyal Raz
Oct 19, 2011·The Journal of Infectious Diseases·Peter HalfmannYoshihiro Kawaoka
Apr 7, 2011·Virology Journal·Lan-Juan ZhaoZhong-Tian Qi
Mar 14, 2012·Mutation Research. Reviews in Mutation Research·Christina SchleckerJörn Lötsch
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ying HuangSeng-Lai Tan
Mar 25, 2019·International Journal of Molecular Sciences·Megan L StaniferSteeve Boulant
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bobbie Ann AustinDaniel J J Carr
Feb 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhiming ShuChaobin Liu
Jun 30, 2006·Biochemical and Biophysical Research Communications·Atsushi HosuiNorio Hayashi
Feb 12, 2009·Gastroenterology·Hironobu TsukadaKazuaki Chayama
Apr 23, 2010·Cytokine·Sonali JoshiLeonidas C Platanias

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