Involvement of peptidylprolyl cis/trans isomerases in Enterococcus faecalis virulence.

Infection and Immunity
Fany ReffuveilleAlain Rince

Abstract

Peptidylprolyl cis/trans isomerases (PPIases) are enzymes involved in protein folding. Analysis of the genome sequence of Enterococcus faecalis V583 allowed for identification of 3 PPIases carrying genes. ef2898 encodes an intracellular PPIase which was not shown to be important for the E. faecalis stress response or virulence. The other two PPIases, the parvulin family rotamase EF0685 and the cyclophilin family member EF1534, are expected to be surface-exposed proteins. They were shown to be important for virulence and resistance to NaCl. A Δef0685 Δef1534 mutant was also more resistant to oxidative stress, was able to grow under a high manganese concentration, and showed altered resistance to ampicillin and quinolone antibiotics.

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Citations

Dec 10, 2015·Interdisciplinary Sciences, Computational Life Sciences·Shama KhanMd Imtaiyaz Hassan
Jan 20, 2017·Virulence·H M Sharon GohKimberly A Kline
Jan 7, 2017·World Journal of Microbiology & Biotechnology·Eirini-Evangelia ThomloudiMaria Dimou
Aug 10, 2017·World Journal of Microbiology & Biotechnology·Maria DimouPanagiotis Katinakis
Jul 11, 2019·The Journal of Infectious Diseases·F Romero-SaavedraJ Huebner
Nov 6, 2020·Cells·Ermioni Kalfopoulou, Johannes Huebner
Aug 14, 2020·Journal of Medicinal Chemistry·Nicolas ScheupleinMitali Sarkar-Tyson

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