PMID: 11902807Mar 21, 2002Paper

Involvement of peripheral cyclooxygenase-1 and cyclooxygenase-2 in inflammatory pain

The Journal of Pharmacy and Pharmacology
Rosa Ventura MartínezFrancisco J López-Muñoz

Abstract

Pain-induced functional impairment in the rat (PIFIR) is a model of inflammatory and arthritic pain similar to that of clinical gout. Nociception is induced by the intra-articular injection of uric acid into the right hind limb, inducing its dysfunction. Animals then receive analgesic drugs and the recovery of functionality over time is assessed as an expression of antinociception. We have examined the role of peripheral prostaglandins synthesized by cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in inflammatory pain using the PIFIR model. Rofecoxib (a selective COX-2 inhibitor) and SC-560 (a selective COX-1 inhibitor) both produced dose-dependent effects. When the inhibitors were administered before uric acid, they showed similar potency, but the antinociceptive efficacy of SC-560 was lower than rofecoxib; the best antinociceptive effects were obtained with the dose of 100 microg/articulation of each inhibitor (pre-treatment). In post-treatment (inhibitors administered after the uric acid), rofecoxib showed the least antinociceptive effect and SC-560 was more potent than rofecoxib. The inhibition of both COX-1 and COX-2 produced a more profound analgesic effect than the inhibition of either COX-1 or COX-2 alone. The pre...Continue Reading

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Citations

Feb 19, 2005·Psychopharmacology·A Fernández-GuastiF J López-Muñoz
Nov 24, 2007·Archives of Orthopaedic and Trauma Surgery·Bruce E RapuanoDavid L Helfet
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Jun 3, 2008·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Gary S FantonGregory A Demopulos
May 10, 2006·British Journal of Pharmacology·Dymphy R H HuntjensOscar E Della Pasqua
Nov 28, 2012·International Journal of Clinical Practice. Supplement·K D Rainsford
Apr 23, 2004·European Journal of Pharmacology·Satyanarayana S V PadiShrinivas K Kulkarni
Feb 8, 2005·Journal of the Society for Gynecologic Investigation·Charles E Wood
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Jun 18, 2019·Therapeutic Advances in Musculoskeletal Disease·Marcum W CollinsJasvinder A Singh
Jul 6, 2021·The Journal of Pharmacy and Pharmacology·Rosa Ventura-MartínezGabriel Navarrete-Vázquez

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