Involvement of peritoneal dendritic cells in the induction of autoimmune prostatitis

Journal of Autoimmunity
S G CorreaP Iribarren

Abstract

We have been working within a model of autoimmune prostatitis induced by the intraperitoneal administration of saline extract of rat male accessory glands (RAG) associated to liposomes. The intraperitoneal administration of RAG-liposomes elicits both primary and secondary cellular autoimmune responses to RAG as well as organ-specific lesions. To evaluate the participation of dendritic cells (DC) in the induction of the autoimmune response, we purified peritoneal DC (PDC) after a single injection of RAG-liposomes and we characterized this population by morphology and phenotype. Based on adherence and morphologic criteria, we determined that PDC comprised approximately 1% of the total peritoneal cells. The ultrastructure of the dendritic cell enriched fraction was assessed by electron microscopy. By FACS analysis, PDC showed a two to three-fold increase in expression of the IA molecule compared to macrophages. They expressed low but positive levels of the CD14 marker, and intermediate levels of both CD11b (Mac-1) and CD54 (ICAM-1) adhesion molecules. In addition, PDC transferred either intravenously or intraperitoneally efficiently elicited the autoimmune response to RAG in normal receptors. These results support the involvement ...Continue Reading

Citations

Jul 29, 2003·Current Urology Reports·Caroline Maake, Hubert John
Nov 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M Magdalena CanaliSilvia G Correa
Dec 22, 2006·European Urology·Gero KramerMichael Marberger
Feb 26, 2005·Clinical and Experimental Immunology·M L McCullyJ Madrenas
Jun 30, 2016·American Journal of Reproductive Immunology : AJRI·Peng Wang, Yong-Gang Duan
Nov 18, 2020·International Urology and Nephrology·Yuqian LiuXiaohui Zhou
Oct 10, 1998·Clinical Microbiology Reviews·G J Domingue, W J Hellstrom

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