Involvement of phosphodiesterases in autoimmune diseases

Journal of Neuroimmunology
Keren MizrachiSara Fuchs

Abstract

We have previously shown that several phosphodiesterase (PDE) subtypes are up-regulated in muscles and lymph node cells (LNC) of rats with experimental autoimmune myasthenia gravis (EAMG). In the present study we investigated PDE expression during the course of EAMG and experimental allergic encephalomyelitis (EAE) and found that the up-regulated expression of selected PDE subtypes in both experimental models is correlated with disease severity. In EAMG, PDE expression is correlated also with muscle damage. A similar up-regulation of PDE was also observed in the respective human diseases, MG and multiple sclerosis (MS). Our findings suggest that change in PDE expression levels is a general phenomenon in autoimmune diseases and may also be used as a marker for disease severity.

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Citations

Jul 11, 2012·Expert Opinion on Pharmacotherapy·Jordi Díaz-ManeraIsabel Illa
Nov 7, 2012·IUBMB Life·Eva Bollen, Jos Prickaerts
Mar 10, 2017·Alzheimer's Research & Therapy·Raphael HesseChristine A F von Arnim

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