Involvement of Platelets in Cancers

Seminars in Thrombosis and Hemostasis
Diane MegeChristophe Dubois

Abstract

Cancer-related venous thromboembolism (VTE) is frequent and constitutes the second leading cause of death in patients with cancer. High platelet count is one of independent predictive factors of cancer-associated VTE. Besides the implication of platelets in cancer-associated VTE, recent clinical and experimental evidences support that platelets play several roles in the progression of malignancies and inversely, cancer can also influence platelet count and activity. The objective of this report is to review the current literature regarding the role of platelets in cancer through experimental results and population-based studies. Platelets are implicated in cancer progression and metastasis through proangiogenic factors (growth factors and signaling pathways), antiangiogenic factors (angiostatin, endostatin, thrombospondin-1), and matrix metalloproteinases. In addition, platelets are involved in cancer-associated thrombosis and thus tumor cell-induced platelet activation, through anionic phospholipids on their surface, released soluble factors, such as P-selectin, CD40 ligand, platelet factor 4, thrombospondin-1 or beta-thromboglobulin, tumor cell procoagulant proteins (tissue factor, urokinase-type plasminogen activator, plasmi...Continue Reading

Citations

May 27, 2020·Journal of Molecular Recognition : JMR·Aaron G Liebsch, Hermann Schillers
Feb 29, 2020·Journal of Thrombosis and Haemostasis : JTH·Stefan Handtke, Thomas Thiele
Dec 5, 2020·Vascular Health and Risk Management·Salvatore Santo SignorelliMargherita Ferrante
Dec 17, 2020·Thrombosis Journal·Zahra EslamifarSaba Behzadifard
Oct 21, 2020·Bulletin de l'Académie nationale de médecine·C StrasselC Gachet
May 4, 2021·Frontiers in Cell and Developmental Biology·Wolfgang M J ObermannJohannes A Eble
Oct 15, 2020·Current Drug Targets·Lin ZhengJie Yao
Oct 5, 2021·Seminars in Thrombosis and Hemostasis·Emmanuel J Favaloro

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