Involvement of postsynaptic EP4 and presynaptic EP3 receptors in actions of prostaglandin E2 in rat supraoptic neurones

Journal of Neuroendocrinology
I ShibuyaH Yamashita

Abstract

We have reported that supraoptic nucleus (SON) neurones are excited by prostaglandin E2 (PGE2) presumably via dual postsynaptic PG receptors, FP receptors and unidentified EP receptors, and that presynaptic EP receptors may also be involved in the excitation. In the present study, to clarify the receptor mechanism of the PGE2-mediated actions on SON neurones, we studied the pre- and postsynaptic effects of four newly developed EP agonists that are selective for each of the four EP receptors, EP1-4, on rat SON neurones using extracellular recording and whole-cell patch-clamp techniques. The EP4 agonist ONO-AE1-329 mimicked the excitatory effects of PGE2, whereas the EP1 agonist ONO-DI-004, the EP2 agonist ONO-AE1-257 and the EP3 agonist ONO-AE-248 had little or no effect. The effects of ONO-AE1-329 were unaffected by the EP1/FP/TP antagonist, ONO-NT-012, which potently suppressed the excitation caused by the FP agonist fluprostenol and PGE2. ONO-AE1-329 caused marked excitation when responses to fluprostenol were desensitized by repeated applications of fluprostenol. Patch-clamp analysis in SON neurones showed that ONO-AE1-329 induced inward currents at a holding potential of -70 mV and the reversal potential of the currents was...Continue Reading

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Citations

Jan 22, 2003·Journal of Neuroendocrinology·T NagataI Shibuya
Mar 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yoko MatsuokaShuh Narumiya
Sep 13, 2003·Journal of Neuroendocrinology·U KniggeJ Warberg
Mar 20, 2010·Journal of Neuroendocrinology·G LengW E Armstrong
Dec 20, 2005·Brain Research·Abdullah Shafique AhmadSylvain Doré
Feb 13, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M P da SilvaW A Varanda
Sep 8, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Nan Sang, Chu Chen
Jul 26, 2005·Journal of Neuroscience Research·Peimin ZhuChu Chen
Nov 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yassar ChakfeCharles W Bourque
Sep 2, 2011·American Journal of Physiology. Renal Physiology·Rikke NørregaardBoye L Jensen
Aug 26, 2006·International Archives of Allergy and Immunology·J M OldhoffM S de Bruin-Weller
Nov 26, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andrea SchmittPeter J Gebicke-Haerter
Jun 30, 2018·International Journal of Molecular Medicine·Xiaoting Sun, Qi Li
Oct 4, 2006·British Journal of Pharmacology·I DeyK Chadee
Nov 4, 2004·Experimental Biology and Medicine·Nicolas P Turrin, Serge Rivest
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ju ShiKatrin Andreasson
Mar 5, 2009·American Journal of Physiology. Endocrinology and Metabolism·Karine PalinFrançoise Moos

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