PMID: 9423933Jan 10, 1998Paper

Involvement of potentially distinct neurotensin receptors in neurotensin-induced stimulation of striatal [3H]dopamine release evoked by KCl versus electrical depolarization

Neuropharmacology
M HeaulmeP Soubrié

Abstract

We intended to determine whether the effect of neurotensin (NT) on K+ and electrically evoked [3H]dopamine (DA) release from rat and guinea-pig striatal slices involved different mechanisms and/or receptors. In the two species, NT and three NT agonists were found to exhibit different relative potencies to enhance K+- and electrically-evoked [3H]DA release. NT(1-13) increased [3H]DA release with EC50 values in the nanomolar range and Emax values in the range of 100% of control. NT(8-13) and Eisai hexapeptide were both as active as NT(1-13) under K+ depolarization, but did not exceed 40% of the NT(1-13) effect under electrical depolarization. In rats, when [3H]DA release was stimulated with two successive K+ depolarizations, in the presence of NT(1-13), the NT effect during the second exposure to K+ was drastically decreased, suggesting that the NT receptor was desensitized. The desensitization process was essentially observed on Emax values, EC50 values being weakly affected. Similar results were obtained in guinea pig. In contrast, with two electrical depolarizations or with two different depolarizations (K+ followed by electrical), the NT effect during the second depolarization was not significantly affected. Concerning NT ant...Continue Reading

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Citations

May 10, 2005·Brain Research. Molecular Brain Research·Rui WangElliott Richelson
Mar 14, 2000·Life Sciences·L FerraroT Antonelli
Oct 18, 2000·Regulatory Peptides·B M Tyler-McMahonE Richelson
Sep 6, 2003·The European Journal of Neuroscience·Seiichiro MatsuyamaAkinori Nishi

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