Involvement of premacular mast cells in the pathogenesis of macular diseases

PloS One
Takaki SatoTsunehiko Ikeda

Abstract

We previously reported on the elevated intravitreal activities of tryptase and chymase in association with idiopathic epiretinal membrane (ERM) and idiopathic macular hole (MH). In this present study, we investigated the potential intraocular production of these serine proteases, and measured and compared tryptase and chymase activities in the vitreous body and serum in ERM, MH, proliferative diabetic retinopathy (PDR), and rhegmatogenous retinal detachment (RRD) patients. In addition, nuclear staining with hematoxylin and eosin (H&E) and mast-cell staining with toluidine blue were performed on samples of the vitreous core and bursa premacularis (BPM) of MH. We also performed immunostaining on the above two regions of vitreous samples for MH with anti-tryptase antibody, anti-chymase antibody, anti-podoplanin antibody, anti-lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) antibody, and anti-fibroblast antibody. Moreover, we performed immunostaining with anti-tryptase antibody and anti-chymase antibody on ERMs collected intraoperatively. Tryptase activity in the vitreous body was significantly higher in ERM and MH than in PDR. However, no significant differences were observed in the tryptase activity in the serum among...Continue Reading

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Citations

Apr 18, 2019·Lymphatic Research and Biology·Francine Blei
Nov 18, 2019·Journal of Medical Case Reports·Makiko MiyamotoTsunehiko Ikeda
Feb 13, 2021·International Journal of Molecular Sciences·Tsunehiko IkedaHidehiro Oku
Mar 7, 2021·International Journal of Molecular Sciences·Seita MorishitaTsunehiko Ikeda

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