Involvement of prostaglandins in inflammation induced by latex of Calotropis procera

Mediators of Inflammation
V L Kumar, Yatin M Shivkar

Abstract

The aerial parts of the plant Calotropis procera produce milky white latex that causes inflammation of the skin and mucous membranes. Prostaglandins are one of the mediators released in an inflammatory response following induction of cyclooxygenase (COX). In the present study, we have evaluated the role of prostaglandins in inflammatory response elicited by the latex of C. procera. Aqueous extract of dried latex of C. procera was injected into the 6-day air-pouch in the rat. The inflammatory response was evaluated by studying the air-pouch fluid for its volume, protein and prostaglandin (PG) E2 concentrations, and leucocyte counts. The granulation tissue from the pouch was quantified and studied for COX-2 expression by reverse transcriptase-polymerase chain reaction. The inhibitory effect of celecoxib and dexamethasone was evaluated on the aforementioned parameters. Dried latex produced an inflammatory response that was maximum at 6 h. It was associated with the accumulation of protein-rich fluid, leucocytes and PGE2 production. It also resulted in granulation of the pouch cavity that was a maximum on day 3. COX-2 expression could be detected in the granulation tissue on day 1 and it increased progressively up to day 5. The ant...Continue Reading

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Feb 6, 2004·Mediators of Inflammation·Yatin M Shivkar, Vijay L Kumar

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Citations

Mar 19, 2005·ILAR Journal·Jodie A Kulpa-EddyKristina M Adams
Sep 30, 2005·Mediators of Inflammation·Raman Sehgal, Vijay L Kumar
Feb 21, 2006·Mediators of Inflammation·Biswa M Padhy, Vijay L Kumar
Dec 17, 2008·Indian Journal of Ophthalmology·Nidhi PandeySantosh Singh Patel
Jun 5, 2008·International Journal of Andrology·Wendy R WinnallMark P Hedger
Jun 23, 2007·Autonomic & Autacoid Pharmacology·Vijay L Kumar, Raman Sehgal
Jul 31, 2010·Mediators of Inflammation·Wen-Hsiang SuPeng-Hui Wang
Jan 23, 2015·Medical Journal, Armed Forces India·Shrikant Waikar, V K Srivastava
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thais Biondino Sardella GiornoPatricia Dias Fernandes
Aug 25, 2021·Indian Journal of Ophthalmology·Varsha M RathiRohit C Khanna

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