PMID: 9661217Jul 14, 1998Paper

Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone

Prostaglandins & Other Lipid Mediators
H KusuharaT Okumoto

Abstract

Intraperitoneal injection of phenyl-p-benzoquinone (phenylquinone, PQ) induced writhing in mice for up to 30 min. During this time, the peritoneal content of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), a stable degradation product of PG12, was highest in the 15-min. sample. In the peritoneal cells, the mRNA expression for the constitutive cyclooxygenase-1 (COX-1) was unchanged by PQ administration. In contrast, little mRNA for COX-2 was detected in the peritoneal cells from unstimulated animals, and was induced 60-120 min. after PQ administration. PGs involved in the induction of writhing thus seem to be derived from a COX-1 reaction. Oral administration of mofezolac, a non-steroidal anti-inflammatory drug which potently inhibits COX-1, suppressed the PQ-induced writhing and peritoneal accumulation of PGs without affecting mRNA expression for both COX isoforms in mice.

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Citations

May 7, 2002·Life Sciences·Jorge E Torres-LópezVinicio Granados-Soto
Dec 20, 2002·International Immunopharmacology·Shigeyuki MatsuzakiMasataka Majima
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·N V ChandrasekharanDaniel L Simmons
May 31, 2008·European Journal of Pharmacology·Waldiceu A VerriFernando Q Cunha
Dec 4, 2004·The Journal of Pharmacology and Experimental Therapeutics·Jun KatadaAkira Ohashi

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