Involvement of protein kinase A in ethanol-induced locomotor activity and sensitization

Neuroscience
J R FeeT E Thiele

Abstract

Mutant mice lacking the RIIbeta subunit of protein kinase A (regulatory subunit II beta(-/-)) show increased ethanol preference. Recent evidence suggests a relationship between heightened ethanol preference and susceptibility to ethanol-induced locomotor sensitization. It is currently unknown if protein kinase A signaling modulates the stimulant effects and/or behavioral sensitization caused by ethanol administration. To address this question, we examined the effects of repeated ethanol administration on locomotor activity RIIbeta(-/-) and littermate wild-type (RIIbeta(+/+)) mice on multiple genetic backgrounds. Over three consecutive days, mice were given single i.p. saline injections and immediately placed in a locomotor activity apparatus to establish a composite baseline for locomotor activity. Next, mice maintained on a hybrid 129/SvEvxC57BL/6J or pure C57BL/6J genetic background were given 10 i.p. ethanol injections before being placed in the activity apparatus. Each ethanol injection was separated by 3-4 days. To determine if changes in behavior were specific to ethanol injection, naïve mice were tested following repeated daily saline injections. The effects of ethanol injection on locomotor behavior were also assessed u...Continue Reading

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Citations

Sep 12, 2006·Addiction Biology·John C CrabbeGeorge F Koob
Dec 9, 2009·Pharmacology, Biochemistry, and Behavior·Daniela F FukushiroRoberto Frussa-Filho
Mar 16, 2013·Alcoholism, Clinical and Experimental Research·Rémi LegasteloisMickaël Naassila
Aug 19, 2014·Alcoholism, Clinical and Experimental Research·Gretchen M SprowTodd E Thiele
Jul 25, 2021·International Journal of Molecular Sciences·Masaki TanakaYoshihisa Watanabe

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