Involvement of protein kinase C in cAMP regulation of myelin basic protein gene expression

Journal of Neuroscience Research
S Anderson, Robin Miskimins

Abstract

Since synthesis of myelin components has been seen to be stimulated by cAMP in both oligodendrocytes and Schwann cells we have begun investigating the specific sequence(s) in the 5' flanking region of the myelin basic protein (MBP) gene that are responsible for the induction of MBP transcription by cAMP. Using stably transfected cell lines containing various deletions of the MBP promoter directing the bacterial chloramphenicol acetyltransferase (CAT) gene we have identified a region of the MBP gene that is inhibitory to stimulation by increased cAMP levels. This inhibition can be overcome by pretreating the cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) for 48 hr. The effects on MBP gene expression modulated by TPA and cAMP involve altered DNA-protein interactions in the 5' end of the MBP promoter. The effect of TPA also appears to be mediated by down-regulation of protein kinase C.

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Citations

Sep 5, 2002·Journal of Neuroscience Research·Mehreen HaiPragna I Patel
Nov 5, 2002·Brain Research. Developmental Brain Research·Evgeny Bichenkov, John S Ellingson
Feb 28, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R Miskimins, W K Miskimins
May 30, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Robert E ClarkRobin Miskimins
Apr 5, 2013·Glia·Misti MaloneJohn McDonald
Aug 2, 2014·European Journal of Pharmacology·Shinji YamamotoKeisuke Yoshikawa
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K TanakaY Fukuuchi
Jul 1, 1999·Journal of Neurochemistry·V JaquetJ M Matthieu

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