PMID: 7545515May 1, 1995Paper

Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium

British Journal of Pharmacology
G F BaxterD M Yellon

Abstract

Rabbit hearts were preconditioned with four 5 min coronary artery occlusions 24 h before 30 min coronary occlusion with 120 min reperfusion. Preconditioning significantly reduced the percentage of myocardium infarcting within the risk zone from 49.1 +/- 4.3% to 31.8 +/- 3.5% (P < 0.05). When the protein kinase C (PKC) inhibitor, chelerythrine, was administered just before preconditioning, the delayed protection against infarction 24 h later was abolished. We conclude that the delayed cytoprotective response associated with ischaemic preconditioning of myocardium is likely to involve the early activation of one or more PKC subtypes.

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Citations

Nov 5, 2003·Neurourology and Urodynamics·Bruno LorenziAlison F Brading
Nov 1, 1996·Basic Research in Cardiology·Y LiuE Marban
May 25, 2010·Cardiovascular Drugs and Therapy·Derek J Hausenloy, Derek M Yellon
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Sep 12, 2003·Journal of Molecular and Cellular Cardiology·Adrienn KisGary F Baxter
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