Involvement of proteinase-activated receptors 1 and 2 in spreading and phagocytosis by murine adherent peritoneal cells: modulation by the C-terminal of S100A9 protein

European Journal of Pharmacology
R L PaganoRenata Giorgi

Abstract

Proteinase-activated receptors (PAR) are widely recognized for their modulatory properties in inflammatory and immune responses; however, their direct role on phagocyte effector functions remains unknown. S100A9, a protein secreted during inflammatory responses, deactivates activated peritoneal macrophages, and its C-terminal portion inhibits spreading and phagocytosis of adherent peritoneal cells. Herein, the effect of PAR1 and PAR2 agonists was investigated on spreading and phagocytosis by adherent peritoneal cells, as well as the ability of murine C-terminal of S100A9 peptide (mS100A9p) to modulate this effect. Adherent peritoneal cells obtained from mouse abdominal cavity were incubated with PAR1 and PAR2 agonists and spreading and phagocytosis of Candida albicans particles were evaluated. PAR1 agonists increased both the spreading and the phagocytic activity, but PAR2 agonists only increased the spreading index. mS100A9p reverted both the increased spreading and phagocytosis induced by PAR1 agonists, but no interference in the increased spreading induced by PAR2 agonists was noticed. The shorter homologue peptide to the C-terminal of mS100A9p, corresponding to the H(92)-E(97) region, also reverted the increased spreading a...Continue Reading

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Citations

Jul 28, 2012·Current Molecular Medicine·R DonatoC L Geczy
Oct 3, 2014·Mediators of Inflammation·Rosana Lima PaganoRenata Giorgi
May 31, 2014·Blood·Riku DasEdward F Plow
Aug 13, 2013·Periodontology 2000·Georgina S Butler, Christopher M Overall
Dec 4, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xuan XiaoChi Zhang
Nov 20, 2013·Journal of the American Chemical Society·Megan Brunjes BrophyElizabeth M Nolan

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