PMID: 11911990Mar 26, 2002Paper

Involvement of rat lateral septum-acetylcholine pressor system in central amygdaloid nucleus-emotional pressor circuit

Neuroscience Letters
Yao-Hua Li, Yun-Hui Ku

Abstract

There is an emotional pressor circuit composed of nuclei controlling emotion and stress, which may be the neurophysiological basis for prolonged emotional stress inducing hypertension. The central amygdaloid nucleus (AC) is the most important in this circuit, which widely connects with the other nuclei via its CRF (corticotropin releasing factor)-ergic and SP (substance P)-ergic projection fibers. There is another pressor system composed of the lateral septum (SL), habenula (HB), locus coeruleus (LC), and rostral ventrolateral medulla (RVL); muscarinic receptors are involved in each connection of this system. In view of the facts that the SL also plays an important role in integration of emotion and autonomic reaction, and the AC projects to the SL, it is likely that the SL-acetylcholine (ACh) pressor system is involved in the AC-emotional circuit. The present study demonstrates that injection of receptor blocker into each nucleus in the SL-ACh pressor pathway can reverse the AC pressor response, proving that the SL-HB (and HB-posterior hypothalamus)-LC-RVL pressor system is a component of the AC-emotional pressor circuit.

References

Sep 1, 1979·The Journal of Comparative Neurology·M Herkenham, W J Nauta
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Nov 12, 1990·Brain Research·H KimuraP L McGeer

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Citations

May 25, 2005·Basic & Clinical Pharmacology & Toxicology·Edward G Smith, Christopher J Gordon
Jan 27, 2016·Neuroscience·Charles J VierckRonald G Wiley
Aug 7, 2004·Brain Research. Brain Research Reviews·Teige P SheehanDavid S Russell
Aug 2, 2006·Autonomic & Autacoid Pharmacology·J Myslivecek, R Kvetnanský
Oct 19, 2011·The Journal of Physiology·Robert T R Huckstepp, Nicholas Dale
Jun 25, 2005·The Journal of Comparative Neurology·Nerea Moreno, Agustín González

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