PMID: 9537373Apr 16, 1998Paper

Involvement of recF, recO, and recR genes in UV-radiation mutagenesis of Escherichia coli

Journal of Bacteriology
Y H LiuT C Wang

Abstract

The recF, recO, and recR genes were originally identified as those affecting the RecF pathway of recombination in Escherichia coli cells. Several lines of evidence suggest that the recF, recO, and recR genes function at the same step of recombination and postreplication repair. In this work, we report that null mutations in recF, recO, or recR greatly reduce UV-radiation mutagenesis (UVM) in an assay for reversion from a Trp- (trpE65) to a Trp+ phenotypes. Introduction of the defective lexA51 mutation [lexA51(Def)] and/or UmuD' into recF, recO, and recR mutants failed to restore normal UVM in the mutants. On the other hand, the presence of recA2020, a suppressor mutation for recF, recO, and recR mutations, restored normal UVM in recF, recO, and recR mutants. These results indicate an involvement of the recF, recO, and recR genes and their products in UVM, possibly by affecting the third role of RecA in UVM.

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Citations

Nov 20, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kendric C Smith
Oct 6, 2000·Annual Review of Microbiology·M Riley, M H Serres
Nov 20, 2008·The Journal of Biological Chemistry·Nodar MakharashviliSergey Korolev
Jan 29, 2008·The Journal of Biological Chemistry·Gali AradZvi Livneh
Feb 12, 2020·Science Advances·Jonathan H BethkeLingchong You
Nov 1, 2012·EcoSal Plus·Bénédicte Michel, David Leach
Oct 2, 2004·Structure·Nodar MakharashviliSergey Korolev
May 20, 2009·Genes & Development·Naofumi HandaStephen C Kowalczykowski

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