PMID: 2124506Nov 13, 1990Paper

Involvement of Rh blood group polypeptides in the maintenance of aminophospholipid asymmetry

Biochemistry
A J SchroitJ P Cartron

Abstract

The human erythrocyte (RBC) Rh blood group system consists of a complex of distinct integral membrane polypeptides with physical properties common to the aminophospholipid transporter responsible for the transbilayer movement of phosphatidylserine (PS) in RBC. To assess the involvement of Rh polypeptides in PS translocation, the aminophospholipid translocase was labeled with a photoactivatable PS analogue, 125I-azido-PS, and with an inhibitor of PS transport, 125I-labeled 2-(2-pyridyldithio)ethylamine. The ability of monoclonal Rh antibodies to immunoprecipitate the labeled transporter was determined. Immunoprecipitated Rh polypeptides were found to be labeled with the aminophospholipid translocase markers, suggesting that Rh proteins are involved in the transbilayer movement of PS.

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B Chérif-ZaharY Colin
Jan 1, 1989·The Journal of Clinical Investigation·A M SabooriP Agre
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A M SabooriP Agre
Sep 24, 1985·Biochemistry·D L Daleke, W H Huestis
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M Seigneuret, P F Devaux
Apr 5, 1982·FEBS Letters·C G Gahmberg

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Citations

Apr 5, 2002·Medicinal Research Reviews·J Middleton Boon, Bradley D Smith
Oct 1, 1994·Molecular and Biochemical Parasitology·A BermanL Tilley
Nov 13, 1991·Biochimica Et Biophysica Acta·A J Schroit, R F Zwaal
May 4, 1999·Blood Reviews·G Daniels
Aug 14, 2001·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J P Cartron, Y Colin
Jun 17, 2000·Biochimica Et Biophysica Acta·D L Daleke, J V Lyles
Aug 14, 1999·Biochimica Et Biophysica Acta·E M BeversR F Zwaal
Apr 9, 2008·Current Opinion in Hematology·Lesley J Bruce
Nov 30, 1992·Annals of the New York Academy of Sciences·D L DalekeM Zimmerman
Dec 10, 2002·Annual Review of Physiology·Krishnakumar Balasubramanian, Alan J Schroit
May 13, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J LiberaA Herrmann
Mar 24, 1999·Molecular Membrane Biology·S FrickenhausR Heinrich
Dec 1, 1991·Baillière's Clinical Haematology·P Agre, J P Cartron
Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S CribierA Zachowski
Jun 1, 1993·Baillière's Clinical Haematology·D J Anstee, M J Tanner
Apr 8, 2006·Chemistry and Physics of Lipids·Philippe F DevauxSusanne Bryde
Jul 10, 2003·Clinics in Laboratory Medicine·Neal S Rote, Bradley P Stetzer
Feb 25, 1998·Biochemical and Biophysical Research Communications·S IwamotoE Kajii
Jul 15, 2000·Baillière's Best Practice & Research. Clinical Haematology·J P Cartron
Nov 16, 1993·Biochemistry·M L Zimmerman, D L Daleke
Aug 1, 1994·Lupus·E M BeversR F Zwaal
Nov 22, 2001·Immunology Letters·Lise Nickerson, Erik J Wiersma
Jun 12, 1998·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J P Cartron

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