Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in lipopolysaccharide-induced pulmonary inflammation

The American Journal of Pathology
Peter H YuC Stolen

Abstract

Semicarbazide-sensitive amine oxidase (SSAO) resides on the vascular endothelium and smooth muscle cell surface and is capable of deaminating short chain aliphatic amines and producing toxic aldehydes and hydrogen peroxide. The enzyme, also known as a vascular adhesion protein-1, is involved in the inflammation process. This intriguing protein with dual functions is increased in the serum of diabetic and heart failure patients. In the present study we assessed the involvement of SSAO in a lipopolysaccharide-induced pulmonary inflammation model using transgenic mice that overexpress human vascular adhesion protein-1. Overexpression of SSAO activity increased the formation of protein-formaldehyde deposits in tissues. Lysine residues of proteins were the primary targets for cross-linkage with formaldehyde derived from deamination of methylamine. Lipo-polysaccharide-induced increases in inflammatory cells in the bronchoalveolar lavage (BAL) fluid were significantly higher in the transgenic than in the nontransgenic mice. BAL cell counts were also higher in the untreated transgenic than in nontransgenic mice. Blocking SSAO activity with a selective inhibitor significantly reduced the number of neutrophils as well as levels of macrop...Continue Reading

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Citations

Dec 9, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Karin ErnbergJ Mitchell Guss
Mar 19, 2014·Seminars in Immunopathology·Marko Salmi, Sirpa Jalkanen
Aug 20, 2015·Critical Reviews in Clinical Laboratory Sciences·Roos PannecoeckMarijn M Speeckaert
Jun 17, 2011·Expert Opinion on Therapeutic Patents·Petra DunkelPéter Mátyus
Nov 11, 2008·European Journal of Immunology·Jan KissMarko Salmi
Oct 4, 2007·Annals of the New York Academy of Sciences·Patricia F LalorDavid H Adams
Apr 19, 2015·Respiratory Research·Heidi C SchilterWolfgang Jarolimek
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Tuanjie Chang, Lingyun Wu
Dec 5, 2006·ChemMedChem·Francesc YraolaMiriam Royo
Aug 15, 2013·The Journal of Pharmacology and Experimental Therapeutics·Jonathan S FootWolfgang Jarolimek
Jun 29, 2007·The Journal of Pharmacology and Experimental Therapeutics·Michael KazachkovPeter H Yu
Mar 3, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fumiko Marttila-IchiharaMarko Salmi
Oct 27, 2017·Antioxidants & Redox Signaling·Marko Salmi, Sirpa Jalkanen

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