Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats

Neuroscience Letters
Takayuki IshiwataBenjamin N Greenwood

Abstract

We have recently reported that the serotonin (5-HT) projections from the midbrain's raphe nuclei that contains 5-HT cell bodies may play a role both in heat production and in heat loss. The purpose of the present study was to clarify the involvement of 5-HT in the ventral tegmental area (VTA), where 5-HT is suggested to participate in thermoregulation, using the combined methods of telemetry, microdialysis, and high performance liquid chromatography, with a special emphasis on regulation of the body temperature (Tb) in freely moving rats. First, we measured changes in Tb, tail skin temperature (Ttail; an index of heat loss), heart rate (HR; an index of heat production), locomotor activity (Act), and levels of extracellular monoamines in the VTA during cold (5°C) or heat (35°C) exposure. Subsequently, we perfused citalopram (5-HT re-uptake inhibitor) into the VTA and measured the thermoregulatory parameters and monoamines release. Although Tb, Ttail, and HR changed during both exposures, significant changes in extracellular level of 5-HT (138.7±12.7% baseline, p<0.01), but not dopamine (DA) or noradrenaline (NA) were noted in the VTA only during heat exposure. In addition, perfusion of citalopram into the VTA increased extracell...Continue Reading

Citations

Jul 20, 2018·International Journal of Environmental Research and Public Health·Mare Lõhmus
Aug 22, 2020·The International Journal of Neuropsychopharmacology·Tsuyoshi OkadaShiro Suda
Oct 1, 2020·AIMS Neuroscience·Carmelo M Vicario, Gabriella Martino
Aug 24, 2021·Journal of Thermal Biology·Hikaru Nakagawa, Takayuki Ishiwata
Sep 24, 2021·Neurotoxicity Research·Jan van AmsterdamWim van den Brink

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