Involvement of sonic hedgehog and notch signaling in regenerative neurogenesis in adult zebrafish optic tectum after stab injury

The Journal of Comparative Neurology
Yuto UedaToshio Ohshima

Abstract

Unlike humans and other mammals, adult zebrafish have the superior capability to recover from central nervous system (CNS) injury. We previously found that proliferation of radial glia (RG) is induced in response to stab injury in optic tectum and that new neurons are generated from RG after stab injury. However, molecular mechanisms which regulate proliferation and differentiation of RG are not well known. In the present study, we investigated Shh and Notch signaling as potential mechanisms regulating regeneration in the optic tectum of adult zebrafish. We used Shh reporter fish and confirmed that canonical Shh signaling is activated specifically in RG after stab injury. Moreover, we have shown that Shh signaling promotes RG proliferation and suppresses their differentiation into neurons after stab injury. In contrast, Notch signaling was down-regulated after stab injury, indicated by the decrease in the expression level of her4 and her6, a target gene of Notch signaling. We also found that inhibition of Notch signaling after stab injury induced more proliferative RG, but that inhibition of Notch signaling inhibited generation of newborn neurons from RG after stab injury. These results suggest that high level of Notch signalin...Continue Reading

References

Sep 27, 1996·Neuroscience Letters·C H KimN Miki
Jun 19, 2004·Science·Lawrence Lum, Philip A Beachy
Sep 3, 2004·Development·Jason R SpenceKatia Del Rio-Tsonis
Sep 24, 2004·The Journal of Comparative Neurology·Bettina SeriArturo Alvarez-Buylla
Dec 18, 2004·Development·Verónica PalmaAriel Ruiz i Altaba
Jun 14, 2005·The Journal of Comparative Neurology·Günther K H ZupancFred H Gage
Jan 13, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria KasperFritz Aberger
Jul 29, 2006·BMC Developmental Biology·Pamela A RaymondJohn J Perkowski
Feb 7, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jan KaslinMichael Brand
Nov 6, 2008·Journal of Physiology, Paris·Günther K H Zupanc
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nduka M AmankulorEric C Holland
Nov 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Steffen ScholppAndrew Lumsden
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Prisca ChapoutonLaure Bally-Cuif
Sep 30, 2010·The Journal of Comparative Neurology·Rajesh RamachandranDaniel Goldman
Jan 12, 2011·The European Journal of Neuroscience·Carmen G FeijóoVerónica A Palma
Apr 1, 2011·The Journal of Comparative Neurology·Prisca ChapoutonLaure Bally-Cuif
May 20, 2011·Developmental Neurobiology·Caghan KizilMichael Brand
Oct 27, 2011·Disease Models & Mechanisms·Norihito KishimotoKazunobu Sawamoto
Apr 24, 2012·Hormones and Behavior·Nicolas DiotelElisabeth Pellegrini
Sep 14, 2013·Trends in Cell Biology·Nikos KyritsisMichael Brand
Sep 17, 2013·PloS One·Vanessa de Oliveira-CarlosMichael Brand
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Long ZhaoCaroline E Burns
Aug 6, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Miki DozawaToshio Ohshima
Oct 24, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clay ConnerDavid R Hyde
Mar 5, 2016·Development·Alessandro Alunni, Laure Bally-Cuif

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Citations

Feb 29, 2020·World Journal of Stem Cells·Alessandro Zambusi, Jovica Ninkovic
Jul 17, 2021·Frontiers in Cell and Developmental Biology·Yuki Shimizu, Takashi Kawasaki

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