PMID: 8943018Nov 26, 1996Paper

Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes

Proceedings of the National Academy of Sciences of the United States of America
J D GravesE A Clark

Abstract

Despite intensive efforts, the intracellular signaling pathways that mediate apoptosis remain unclear. The human B lymphoma cell line, B104, possesses characteristics that make it an attractive model for analysis of receptor-mediated apoptosis. Although these cells express both membrane IgM (mIgM) and membrane IgD (mIgD) crosslinking mIgM results in significant apoptosis while crosslinking mIgD does not. Our results show that crosslinking mIgM but not mIgD induced a delayed and sustained activation of the mitogen-activated protein kinase (MAPK) family members stress-activated protein kinase (SAPK) and p38 MAPK. The calcium ionophore ionomycin, which also induces apoptosis in B104 cells, stimulated a similar SAPK and p38 MAPK response. Cyclosporin A, a potent inhibitor of apoptosis induced by either mIgM or ionomycin, inhibited activation of both SAPK and p38 MAPK, suggesting that stimulation of these kinases may be required for induction of apoptosis. Collectively, our results indicate that SAPK and p38 MAPK may be downstream targets during mIgM-induced, calcium-mediated, apoptosis in human B lymphocytes.

References

Dec 1, 1991·Cell Regulation·M H CobbD J Robbins
Nov 24, 1995·Science·Z XiaM E Greenberg
Sep 7, 1995·Annals of the New York Academy of Sciences·J D GravesE G Krebs
Nov 17, 1995·The Journal of Biological Chemistry·R M KramerE M Johnstone
Apr 1, 1995·Current Opinion in Immunology·F MelchersJ Andersson
Nov 1, 1995·The Journal of Cell Biology·F Shibasaki, F McKeon
Jan 1, 1995·Current Topics in Microbiology and Immunology·D J McConkey, S Orrenius
Feb 1, 1995·Current Opinion in Genetics & Development·A H Wyllie
Mar 10, 1995·Science·H Steller
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Feb 1, 1994·European Journal of Immunology·N Bonnefoy-BerardJ P Revillard
Jan 12, 1996·The Journal of Biological Chemistry·Y R ChenT H Tan
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·C C Goodnow

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Citations

Jan 19, 2012·Apoptosis : an International Journal on Programmed Cell Death·Nabendu BiswasSantu Bandyopadhyay
Jun 1, 2000·Advances in Enzyme Regulation·E G Krebs, J D Graves
Aug 24, 1999·Pharmacology & Therapeutics·J D Graves, E G Krebs
Jun 1, 1997·Current Opinion in Immunology·A L DeFranco
Mar 17, 2010·Immunology and Cell Biology·Mariya Y YurchenkoSvetlana P Sidorenko
Oct 14, 2000·Cell Research·D Donjerković, D W Scott
Sep 1, 2005·The Journal of Experimental Medicine·Yan XingNobuo Sakaguchi
Sep 7, 2002·Antioxidants & Redox Signaling·Jinsong HeHirohei Yamamura
Aug 28, 1999·International Immunology·K HorikawaT Yamamoto
Jul 21, 1998·Annals of the New York Academy of Sciences·M Punyiczki, L Fésüs
Oct 6, 1998·Annual Review of Biochemistry·E G Krebs
Jan 1, 1997·Annual Review of Cell and Developmental Biology·S M Thomas, J S Brugge
Jun 8, 1999·Annual Review of Immunology·T Kurosaki
Jan 26, 2005·American Journal of Respiratory Cell and Molecular Biology·Takechiyo YamadaAndrew Saxon
Nov 28, 2002·Biological Chemistry·Yu Shi, Matthias Gaestel
Oct 12, 2000·Biochemical and Biophysical Research Communications·J M Swart, T C Chiles
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·J LotemL Sachs
Sep 13, 2008·The International Journal of Neuroscience·Hyun-Ja JeongSeung-Heon Hong
Jan 5, 2001·Expert Opinion on Investigational Drugs·S M KornblauM Andreeff
Jan 19, 2016·Biochemical and Biophysical Research Communications·Beate HeizmannPhilippe Kastner
Jan 22, 2004·Molecular Reproduction and Development·Kirsten C SadlerAndré Picard
Nov 23, 2007·Toxicology and Applied Pharmacology·Cheol ParkYung Hyun Choi
Feb 14, 2004·Immunological Reviews·Jonathan D GravesEdward A Clark

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