PMID: 8597880Nov 1, 1995Paper

Involvement of substance P as a mediator in capsaicin-induced mouse ear oedema

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
H InoueY Koshihara

Abstract

We examined the involvement of substance P (SP) in mouse ear oedema induced by topical application of capsaicin (250 micrograms/ear). Reapplication of capsaicin at 4 h, 24 h, and 48 h after initial treatment did not induce a second oedema response. Oedema induced after the second application was significantly (p < 0.01 or p < 0.001) suppressed for up to 30 days but was observed when capsaicin was applied 40 days after initial treatment. Topical pretreatment of ears with capsaicin at 4 h, 24 h and 48 h before i.v. injection of SP (5 micrograms/kg) did not cause a significant inhibition of plasma extravasation in ear skin. NK1 receptor antagonists such as RP 67580 (ED50:0.19 mg/kg, i.v.), spantide II (ED50:0.33 mg/kg, i.v.), and GR 82334 (ED50:0.26 mg/kg, i.v.), inhibited capsaicin-induced ear oedema, whereas SR 48968 (2.0 mg/kg, i.v.), a NK2 receptor antagonist, had no effect. Furthermore, RP 67580 (0.5 kg/mg, i.v.) inhibited the oedema response induced by reapplication of capsaicin at 50 days after initial treatment. These results indicate that tachyphylaxis of capsaicin-induced oedema is reversible and suggest that this response may be due mainly to a reduction of SP in sensory neurones but not to any loss of responsiveness of...Continue Reading

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Citations

Jun 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H InoueY Koshihara
Aug 27, 1997·European Journal of Pharmacology·H InoueY Koshihara
Feb 11, 1998·General Pharmacology·M YamabeM Misawa
Feb 23, 1999·Fundamental & Clinical Pharmacology·G BlazsóM Gábor
Nov 18, 2006·American Journal of Respiratory and Critical Care Medicine·Yoichi ChidaChiharu Kubo
Oct 2, 2012·Endocrinology·Youping Wang, Donna H Wang
May 24, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Punit P ShahMandip Singh
Sep 30, 2010·Fitoterapia·Gerlânia de O LeiteAdriana R Campos
May 31, 2014·BioMed Research International·Natália Ramos PachecoElita Scio
Dec 3, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Punit P ShahMandip Singh
Oct 12, 2016·Journal of Neuroinflammation·Frances CorriganRobert Vink
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Michael D SouthallJeffrey B Travers
Feb 28, 2017·Food Science and Biotechnology·Seok-Cheol ChoBu Young Choi

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